| 4-Chloro-4'-hydroxybenzophenone Basic information |
| Product Name: | 4-Chloro-4'-hydroxybenzophenone |
| Synonyms: | 4-hydroxy-4’-chloro-benophenone;Fenofibrate Impurity Ⅰ:4-Chloro-4'-hydroxybenzophenone;4-Chloro-4'-Hydroxybenzophenone 4-Hydroxy-4'-Chlorobenzophenone;4-p-Chlorobenzoylphenol;4-(4-Chlorobenzoyl)-4-Hydroxypiperidine;4-(4-CHLOROBENZOYL)PHENOL;4-Chloro-4'-hydroxybenzophenon;LABOTEST-BB LT00248477 |
| CAS: | 42019-78-3 |
| MF: | C13H9ClO2 |
| MW: | 232.66 |
| EINECS: | 255-627-4 |
| Product Categories: | Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Pharmaceuticals;FINE Chemical & INTERMEDIATES;Aromatics;Intermediates & Fine Chemicals;Metabolites & Impurities;Aromatic Benzophenones & Derivatives (substituted) |
| Mol File: | 42019-78-3.mol |
| 4-Chloro-4'-hydroxybenzophenone Chemical Properties |
| Melting point | 177-181 °C |
| Boiling point | 257 °C (13 mmHg) |
| density | 1.2082 (rough estimate) |
| refractive index | 1.5434 (estimate) |
| Fp | 100 °C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| form | neat |
| pka | 7.68±0.15(Predicted) |
| color | Pale Beige to Light Brown |
| BRN | 2049956 |
| CAS DataBase Reference | 42019-78-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Methanone, (4-chlorophenyl)(4-hydroxyphenyl)-(42019-78-3) |
| Safety Information |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-20/21/22 |
| Safety Statements | 24/25-37/39-26-36 |
| Hazard Note | Irritant |
| HS Code | 29144000 |
| MSDS Information |
| Provider | Language |
|---|---|
| (4-Chlorophenyl)(4-hydroxyphenyl)-Methanone | English |
| ACROS | English |
| ALFA | English |
| 4-Chloro-4'-hydroxybenzophenone Usage And Synthesis |
| Chemical Properties | light grey to beige-brown powder |
| Uses | The Impurity of Fenofibric acid (42017-89-0), the active metabolite of fenofibrate which increases Apolipoprotein A-I–Mediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptor |
| Uses | 4-Chloro-4’-hydroxybenzophenone (Fenofibrate EP Impurity A; Fenofibrate USP Related Compound A) the impurity of Fenofibric acid (42017-89-0), the active metabolite of fenofibrate which increases Apolipoprotein A-I–Mediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptor–dependent manner. |
| Preparation | Preparation by Fries rearrangement of phenyl p-chloro-benzoate, ? in the presence of aluminium chloride, without solvent, at 160° for 5 min, between 120° and 160° (good yield) or at 130° for 1 h, then at 160° for 1 h (10%) or in refluxing chlorobenzene for 10 h (52%); ? in the presence of trifluoromethanesulfonic acid at 45–55° (94%). |
| 4-Chloro-4'-hydroxybenzophenone Preparation Products And Raw materials |
| Raw materials | Aluminum chloride-->Anisole-->4-Chlorobenzoyl chloride-->4-Chlorophenylacetylene-->4-chloro-4'-methoxybenzophenone-->SYN-BENZALDEHYDE OXIME-->4-chloro-4'-fluorobenzophenone-->4-CHLORO-4'-NITROBENZOPHENONE |
| Preparation Products | Fenofibric acid |
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