N-Methyl-4-piperidinol

CAS No.：106-52-5

Other grades of this product :

N-Methyl-4-piperidinol Basic information

Product Name:	N-Methyl-4-piperidinol
Synonyms:	1-methyl-4-piperidino;1-Methylpiperidinol-(4);4-Piperidinol, 1-methyl-;N-Methylpiperidol;4-HYDROXY-1-METHYLPIPERIDINE;4-HYDROXY-N-METHYLPIPERIDINE;N-METHYL-4-HYDROXY PIPERIDINE;NM4PPOL
CAS:	106-52-5
MF:	C6H13NO
MW:	115.17
EINECS:	203-406-8
Product Categories:	Building Blocks;C5 to C7;PHARMACEUTICAL INTERMEDIATES;Chemical Synthesis;Heterocyclic Building Blocks;Piperidines;Piperidine
Mol File:	106-52-5.mol

N-Methyl-4-piperidinol Chemical Properties

Melting point	29-31 °C(lit.)
Boiling point	200 °C(lit.)
density	0.98 g/mL at 20 °C(lit.)
vapor pressure	8.13-11Pa at 25℃
refractive index	n20/D 1.479
Fp	190 °F
storage temp.	2-8°C
form	Liquid After Melting
pka	14.87±0.20(Predicted)
color	Clear colorless to brown
Water Solubility	MISCIBLE
Sensitive	Hygroscopic
BRN	103024
LogP	-0.14-0.756 at 25℃
CAS DataBase Reference	106-52-5(CAS DataBase Reference)
NIST Chemistry Reference	4-Hydroxy-N-methylpiperidine(106-52-5)
EPA Substance Registry System	4-Piperidinol, 1-methyl- (106-52-5)

Safety Information

Hazard Codes	Xi,C
Risk Statements	37/38-41-36/37/38-34
Safety Statements	26-37/39-45-36/37/39-27
WGK Germany	3
Hazard Note	Irritant
TSCA	Yes
HS Code	29333999

MSDS Information

Provider	Language
1-Methyl-4-piperidinol	English
SigmaAldrich	English
ACROS	English
ALFA	English

N-Methyl-4-piperidinol Usage And Synthesis

Chemical Properties	clear colorless to yellowish liquid after melting
Uses	Reactant for:• ;Optimization of Novobiocin scaffold to product antitumor agents1• ;Substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis2Reactant for synthesis of:• ;CaMKII inhibitors3• ;VEGFR and FGFR kinase inhibitors4• ;Phosphoinositide-3-kinase inhibitors5• ;Protein lysine methyltransferase G9a inhibitors6
Uses	4-Hydroxy-1-methylpiperidine is used as reactant for optimization of Novobiocin scaffold to product antitumor agents, substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis. It is also used as a reactant in the synthesis of CaMKII, VEGFR and FGFR kinase inhibitors and Phosphoinositide-3-kinase, Protein lysine methyltransferase G9a inhibitors.
Flammability and Explosibility	Notclassified

N-Methyl-4-piperidinol Preparation Products And Raw materials

Raw materials	1-Methyl-4-piperidone-->1-methyl-4-phenylpiperidin-4-ol-->N,N-DI-(BETA-CARBOETHOXYETHYL)METHYLAMINE-->1-Methyl-4(1H)-pyridinone-->1-Methyl-4-oxopiperidin-3-carboxylic acid ethyl ester-->N-(1-METHYLPIPERIDIN-4-YL)ANILINE-->3-HYDROXYGLUTARONITRILE-->1-Methyl-4-piperidinol hydrochloride-->Aniline-->4-Hydroxypiperidine-->Formaldehyde-->N-Methyl-2-pyrrolidone-->Benzene
Preparation Products	4-(1-METHYLPIPERIDIN-4-YLOXY)-3,5-DICHLOROBENZENAMINE

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