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| GABOXADOL HYDROCHLORIDE Basic information |
| Product Name: | GABOXADOL HYDROCHLORIDE | | Synonyms: | 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-6-ium-3-olate;4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one monohydrochloride;THIP HYDROCHLORIDE (GABOXADOL) POST-SYNA PTIC GABA RE;THIP hydrochloride, 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride;Einecs 285-687-7;Isoxazolo[5,4-c]pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, Monohydrochloride;Gaboxadol hydrochloride solid, >=98% (HPLC);4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol, (HCl salt) | | CAS: | 85118-33-8 | | MF: | C6H9ClN2O2 | | MW: | 176.6 | | EINECS: | 285-687-7 | | Product Categories: | | Mol File: | 85118-33-8.mol |
| GABOXADOL HYDROCHLORIDE Chemical Properties |
| Melting point | 236 °C | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | ethanol: soluble0.91mg/mL | | form | solid | | color | white | | Merck | 14,4321 |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | NY3396800 |
| GABOXADOL HYDROCHLORIDE Usage And Synthesis |
| Uses | GABAergic Agonist | | Uses | Gaboxadol is a sleep aid drug used for the treatment of chronic pain and insomnia. Gaboxadol is also known to exhibit antidepressant like properties through its agonistic activities towards GABA sites
. | | Uses | As a molecular probe to study GABA receptors. | | Uses | Gaboxadol hydrochloride has been used in cell migration and invasion assay to assess liver cancer cell migration. | | General Description | Gaboxadol, also referred to as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a GABA site agonist. It has great affinity to the δ subunit of extrasynaptic high-affinity GABAA receptors. Gaboxadol was first developed for the treatment of schizophrenia, epilepsy, primary insomnia and Huntington′s disease. It can easily cross the blood-brain barrier and is rapidly absorbed by the body. | | Biochem/physiol Actions | GABAA receptor agonist. |
| GABOXADOL HYDROCHLORIDE Preparation Products And Raw materials |
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