3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

CAS No.：641571-11-1

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Basic information

Product Name:	3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
Synonyms:	1-(3-Amino-5-trifluoromethylphenyl)-4-methylimidazole;3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline;3-(4-Methyl-1-imidazolyl)-5-(trifluoromethyl)aniline;Nilotinib EP Impurity A;NILOTINIB IMPURITY 24;4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl) benzene amine;3-(trifluoromethyl)-5-(4-methyl-1H-imidazol-1-yl)benzenamine;3-(4-Methyl-iMidazol-1-yl)-5-trifluoro-MethylphenylaMine
CAS:	641571-11-1
MF:	C11H10F3N3
MW:	241.21
EINECS:	688-269-6
Product Categories:	Nilotinib/Tasigna;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	641571-11-1.mol

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Chemical Properties

Melting point	124-126°C
Boiling point	372.14℃[at 101 325 Pa]
density	1.35
vapor pressure	0Pa at 25℃
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
form	powder to crystal
color	White to Light gray to Light yellow
Water Solubility	228.6mg/L at 25℃
InChIKey	WWTGXYAJVXKEKL-UHFFFAOYSA-N
LogP	2.42
CAS DataBase Reference	641571-11-1(CAS DataBase Reference)

Safety Information

Risk Statements	41
Safety Statements	26-39
RIDADR	2811
HazardClass	6.1
PackingGroup	Ⅲ
HS Code	2933299090

MSDS Information

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Usage And Synthesis

Chemical Properties	Beige Solid
Uses	Intermediate in the preparation of Nilotinib.

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Benzenamine, 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-, hydrochloride (1:1)-->Benzenamine, 3-iodo-5-(trifluoromethyl)--->3-(4-Methylimidazol-1-yl)-5-trifluoromethylbenzoic acid-->3-Amino-5-bromobenzotrifluoride-->1H-IMidazole, 4-Methyl-1-[3-nitro-5-(trifluoroMethyl)phenyl]--->3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide-->3-FLUORO-5-NITROBENZOTRIFLUORIDE-->3-Amino-5-fluorobenzotrifluoride-->4-Methylimidazole-->Benzotrifluoride

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