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| 4-PHENOXYPHENYLBORONIC ACID Basic information |
| 4-PHENOXYPHENYLBORONIC ACID Chemical Properties |
| Melting point | 141-145 °C(lit.) | | Boiling point | 377.0±44.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | pka | 8.76±0.10(Predicted) | | form | Crystalline Powder | | color | White to beige | | InChIKey | KFXUHRXGLWUOJT-UHFFFAOYSA-N | | CAS DataBase Reference | 51067-38-0(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 37/39-26 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29319090 |
| 4-PHENOXYPHENYLBORONIC ACID Usage And Synthesis |
| Chemical Properties | white to off-white powder and chunk | | Uses | suzuki reaction | | Uses | 4-Phenoxybenzeneboronic Acid is an intermediate used to prepare biphenyl derivatives of nitotrifluoromethoxybenzyloxydihydroimidazooxazines with antitubercular activity. It is also used in the synthesis of pyrrolo pyrimidines as potent inhibitors of Lck kinase. | | Uses | 4-Phenoxyphenylboronic acid can be used as a reactant: - In the Suzuki-Miyaura coupling reaction to synthesize aryl derivatives via C-C bond formation by reacting with different aryl halides over a palladium catalyst.
- To prepare 1-phenoxy-4-(trifluoromethyl)benzene via oxidative trifluoromethylation using Chan-Lam-type reaction conditions.
- To synthesize evobrutinib, a potent Bruton′s tyrosine kinase (BTK) inhibitor.
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| 4-PHENOXYPHENYLBORONIC ACID Preparation Products And Raw materials |
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