DBCO-PEG4-Acid

CAS No.：1537170-85-6

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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DBCO-PEG4-Acid Basic information

Product Name:	DBCO-PEG4-Acid
Synonyms:	DBCO-PEG4-Acid;Dibenzocyclooctyne-PEG4-acid;ADIBO-PEG4-acid 90% (HPLC);ADIBO-PEG4-acid;DBCO-PEG4-acid,DBCO-PEG4-COOH;DBCO-CONH-PEG4-acid;DBCO-PEG4-C2-acid;Aurumpharma u63872
CAS:	1537170-85-6
MF:	C30H36N2O8
MW:	552.62
EINECS:
Product Categories:
Mol File:	1537170-85-6.mol

DBCO-PEG4-Acid Chemical Properties

Boiling point	839.7±65.0 °C(Predicted)
density	1.27±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO, DCM, DMF
form	Solid or Viscous Liquid
pka	4.28±0.10(Predicted)
color	Yellow to Orange

Safety Information

MSDS Information

DBCO-PEG4-Acid Usage And Synthesis

Description	DBCO-PEG4-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain allows for increased water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Uses	Acid functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. The PEG spacer adds hydrophilicity to the product to decrease aggregation.

DBCO-PEG4-Acid Preparation Products And Raw materials

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