Product

IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER

CAS No.：39028-27-8

Other grades of this product :

IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER Basic information

Product Name:	IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER
Synonyms:	N-HydroxysucciniMide Iodoacetic Acid Ester;N-IodoacetoxysucciniMide;Iodoacetic Acid N-Succinimidyl Ester N-(Iodoacetoxy)succinimide;2,5-Pyrrolidinedione, 1-[(iodoacetyl)oxy]-;N-SucciniMidyl iodoacetate(SIA);SIA;N-HYDROXYSUCCINIMIDYL IODOACETATE;NHS IODOACETATE
CAS:	39028-27-8
MF:	C6H6INO4
MW:	283.02
EINECS:
Product Categories:	MTS and Sulfhydryl Active Reagents;Heterobifunctional Crosslinker;Cross Linking Reagents;MTS & Sulfhydryl Active Reagents;Active Esters/AdditivesProtein Modification;heteroXlink;Active Esters/AdditivesSynthetic Reagents;Coupling;Crosslinking;Heterobifunctional Cross-Linking Reagents;Peptide Synthesis
Mol File:	39028-27-8.mol

IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER Chemical Properties

Melting point	148°C
Boiling point	315.6±44.0 °C(Predicted)
density	2.11±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMF: 50 mg/mL
form	powder
color	White to Off-White

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
HS Code	29251900

MSDS Information

Provider	Language
SigmaAldrich	English

IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER Usage And Synthesis

Description	SIA Crosslinker is a non-cleavable, water-soluble crosslinker containig an NHS ester and an iodine group. The NHS ester is reactive toward amines while the iodine reacts with thiol groups.
Chemical Properties	White Solid
Uses	A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. Spacer Arm: 1.5 Angstroms
Uses	forms water soluble carboxylate derivatives
Uses	A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. Spacer Arm: 1.5 Angstroms
Biological Activity	SIA Crosslinker is a non-cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs).
in vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER Preparation Products And Raw materials

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