1-METHYL-4-(4-NITROPHENYL)PIPERAZINE

CAS No.：16155-03-6

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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1-METHYL-4-(4-NITROPHENYL)PIPERAZINE Basic information

Product Name:	1-METHYL-4-(4-NITROPHENYL)PIPERAZINE
Synonyms:	1-METHYL-4-(4-NITROPHENYL)PIPERAZINE;1-Methyl-4-(4-nitrophenyl)piperazine95%;1-METHYL-4-(4-NITROPHENYL)PIPERAZINE 95%;Piperazine, 1-Methyl-4-(4-nitrophenyl)-;1-Methyl-4-(4-nitrophenyl)piperizine;1-METHYL-4-(4-NITROPHENYL)PIPERAZIN-1-IUM;1-Methyl-4-(4-nitrophenyl)piperazine,97%;1-METHYL-4-(4-NITROPHENYL)PIPERAZINE ISO 9001：2015 REACH
CAS:	16155-03-6
MF:	C11H15N3O2
MW:	221.26
EINECS:
Product Categories:
Mol File:	16155-03-6.mol

1-METHYL-4-(4-NITROPHENYL)PIPERAZINE Chemical Properties

Melting point	109-111°C
Boiling point	369.5±37.0 °C(Predicted)
density	1.198±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	7.41±0.42(Predicted)
form	Solid

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37/39
HazardClass	IRRITANT
HS Code	29339900

MSDS Information

1-METHYL-4-(4-NITROPHENYL)PIPERAZINE Usage And Synthesis

Chemical Properties	Red solid
Uses	1-methyl-4-(4-nitrophenyl)piperazine was a reagent in the preparation of diaminopyrimidines as reversible and irreversible inhibitors of mutant EGFR tyrosine kinases for treatment of non-small-cell lung cancer. It was also used in the prepn. of disubstituted pyrimidine compds. as EGFR or/and ALK inhibitors useful in the treatment of diseases.

1-METHYL-4-(4-NITROPHENYL)PIPERAZINE Preparation Products And Raw materials

Raw materials

Ethyl acetate-->Methanol-->Potassium carbonate-->Sodium sulfate-->Sodium chloride-->Dimethyl sulfoxide-->4-Chloronitrobenzene-->1-Methylpiperazine-->methanediol-->1-Iodo-4-nitrobenzene-->1-(4-Nitrophenyl)piperazine-->4-Fluoronitrobenzene-->Iodomethane-->Formaldehyde-->Carbon

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