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| GENIPIN Basic information |
| Product Name: | GENIPIN | | Synonyms: | Methyl (1R,2R,6S)-2-hydroxy-9-(hydroxymethyl)-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate;cyclopenta(c)pyran-4-carboxylicacid,1,4a-alpha,5,7a-alpha-tetrahydro-1-hydrox;GENIPIN;1,4a,5,7a-tetrahydro-1-hydroxy-7-(hydroxymethyl)-cyclopenta(c)pyran-4-carboxylic acid methyl ester;Methyl (1S,2R,6S)-2-hydroxy-9-(hydroxymethyl)-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate;(1R)-1,4aα,5,7aα-Tetrahydro-1-hydroxy-7-hydroxymethylcyclopenta[c]pyran-4-carboxylic acid methyl ester;(1R)-1,4aα,5,7aα-Tetrahydro-1α-hydroxy-7-hydroxymethylcyclopenta[c]pyran-4-carboxylic acid methyl ester;enipin | | CAS: | 6902-77-8 | | MF: | C11H14O5 | | MW: | 226.23 | | EINECS: | 636-196-5 | | Product Categories: | Inhibitors;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 6902-77-8.mol |
| GENIPIN Chemical Properties |
| Melting point | 118.0 to 123.0 °C | | Boiling point | 287.83°C (rough estimate) | | density | 1.1230 (rough estimate) | | refractive index | 1.4720 (estimate) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO: ≥25mg/mL | | form | powder | | pka | 12.06±0.60(Predicted) | | color | White to Almost white | | λmax | 240nm(MeOH)(lit.) | | InChIKey | AZKVWQKMDGGDSV-BCMRRPTOSA-N | | CAS DataBase Reference | 6902-77-8(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 3/14-36/37/39 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | GY5828000 | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29329990 |
| GENIPIN Usage And Synthesis |
| Chemical Properties | White powder | | Uses | Genipin is an active aglycone derived from an iridoid glycoside called geniposide, which is found in the fruit of Gardenia jasminoides Ellis. Genipin is a hydrolytic product of geniposide. Genipin has been used in traditional Chinese medicine. Genipin is | | Uses | Genipin is an inhibitor of uncoupling protein 2 (UCP2). | | Uses | Genipin has been used:- in chemosensitivity assay
- in the preparation of recombinant human (rh)-odontogenic ameloblast-associated protein (ODAM) -impregnated collagen gel and in vitro mineralization assay
- in genipin gel preparation
| | General Description | Genipin is a natural cross linking agent, which is extracted from gardenia fruit. It prevents lipid peroxidation and production of nitric oxide. Genipin protects the hippocampal neurons from the toxicity of Alzheimer′s amyloid β protein. It has anti-inflammatory and anti-angiogenesis effects. Genipin is involved in drug delivery system. | | Biochem/physiol Actions | Genipin stimulates insulin secretion in UCP2-dependent manner (Uncoupling protein 2). Genipin is a protein, collagen, gelatin, and chitosan cross-linker. |
| GENIPIN Preparation Products And Raw materials |
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