3-Bromophenol

CAS No.：591-20-8

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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3-Bromophenol Basic information

Product Name:	3-Bromophenol
Synonyms:	M-BROMOPHENOL;3-bromo-pheno;Phenol, m-bromo-;3-Bromophenoles;m-Bromophenoles;m-Bromophenol 3-Bromophenol;m-bromophenol(MBP);3-BROMOPHENOL OEKANAL, 250 MG
CAS:	591-20-8
MF:	C6H5BrO
MW:	173.01
EINECS:	209-706-5
Product Categories:	alcohol\| alkyl bromide;Pyridines;Aromatic Phenols;Phenol&Thiophenol&Mercaptan;Aromatics Compounds;Bromine Compounds;Phenols;Aromatics;Inhibitors;Organic Building Blocks;Oxygen Compounds
Mol File:	591-20-8.mol

3-Bromophenol Chemical Properties

Melting point	30 °C
Boiling point	236 °C(lit.)
density	1,63 g/cm³
refractive index	1.595-1.599
RTECS	SJ7874900
Fp	>230 °F
storage temp.	Store below +30°C.
solubility	alcohol: soluble
form	Liquid
pka	9.03(at 25℃)
color	Clear colorless, yellow or brownish
Specific Gravity	1.610 (20/4℃)
Water Solubility	insoluble
Sensitive	Light Sensitive
Merck	14,1428
BRN	1853950
CAS DataBase Reference	591-20-8(CAS DataBase Reference)
NIST Chemistry Reference	Phenol, 3-bromo-(591-20-8)
EPA Substance Registry System	Phenol, 3-bromo- (591-20-8)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-22-20/21/22
Safety Statements	26-36/39-36/37/39-36
RIDADR	2811
WGK Germany	3
F	8-10-23
Hazard Note	Harmful/Irritant
TSCA	T
HazardClass	6.1(b)
PackingGroup	III
HS Code	29081000
Hazardous Substances Data	591-20-8(Hazardous Substances Data)

MSDS Information

Provider	Language
3-Bromophenol	English
SigmaAldrich	English
ACROS	English
ALFA	English

3-Bromophenol Usage And Synthesis

Chemical Properties	Low-Melting Pale Yellow Semi-Solid. soluble in ether, ethanol and chloroform.
Uses	3-Bromophenol acts as an enzyme inhibitor. It is used in the preparation of 3-bromophenyl ester by reaction with benzoyl chloride in presence of triethylamine as a catalyst. It plays an important role as an intermediate in the manufacture of pharmaceuticals, agrochemicals and dyestuff and in organic synthesis.
Application	3-Bromophenol is an intermediate of organic synthesis and can be used to synthesize 3-bromoanisole; it is also the raw material for the synthesis of anticancer analgesic tramadol, triarylmethane thiophene anti-tuberculosis drugs and 4-aryl piperidine antipruritic drugs.
Preparation	3-bromophenol is synthesized by diazotization and bromination of 3-aminophenol. Dissolve 3-aminophenol in sulfuric acid, cool to below 10°C, and add aqueous sodium nitrite dropwise. After the diazotization reaction, the filtrate is filtered and hydrolyzed with cuprous bromide. Then distillation, collect the evaporated liquid with table salt and filter, the filtrate is extracted with ether, the extract is dried, distilled to recover the ether, and then distilled 3-bromophenol.

3-Bromophenol Preparation Products And Raw materials

Raw materials

Sodium chloride-->Cuprous bromide-->3-Aminophenol

Preparation Products

3-Bromoanisole-->6-BROMO-1-BENZOFURAN-2-CARBOXYLIC ACID-->3-ISOPROPOXYPHENYLBORONIC ACID-->4-BROMO-2-HYDROXYACETOPHENONE-->4-ISOBUTOXYPHENYLBORONIC ACID-->3-MORPHOLINOPHENOL-->3-Benzyloxybenzeneboronic acid-->2，4-Dinitro-1，3-benzene diol-->4-Bromo-2-hydroxybenzaldehyde-->4-BROMO-2-HYDROXYBENZONITRILE-->3-Cyanophenol-->4-Bromo-2-hydroxybenzoic acid-->4,4'-SULFONYLDIPHENOL-->3-(Diphenylamino)phenol-->7-Benzofurancarboxaldehyde (9CI)-->3-(Trifluoromethoxy)bromobenzene

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