(R)-3-Aminoquinuclidine dihydrochloride

CAS No.：123536-14-1

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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(R)-3-Aminoquinuclidine dihydrochloride Basic information

Product Name:	(R)-3-Aminoquinuclidine dihydrochloride
Synonyms:	(R)-(+)-3-Aminoquinuclidine diHCl;(R)-1-AZABICYCLO[2,2,2]OCTAN-3-AMINE DIHYDROCHLORIDE;(R)-(+)-3-Aminoquinuclidine2HCl;1-azabicyclo[2,2,2]octan-3-amine,dihydrochloride,(R)-;(3R)-Quinuclidin-3-amine dihydrochloride 97%;(R)-(+)-3-AMINOQUINUCLIDINE DIHYDROCHLORIDE;(R) 3-AMINOQUINUCLIDINE HYDROCHLORIDE;(3R)-QUINUCLIDIN-3-AMINE DIHYDROCHLORIDE
CAS:	123536-14-1
MF:	C7H16Cl2N2
MW:	199.12
EINECS:
Product Categories:	Chiral Building Blocks;Heterocyclic Building Blocks;Pharmaceutical material and intermeidates;INTERMEDIATESOFPALONOSETRONHYDROCHLORIDE;Ring Systems;Quinuclidines;Amines
Mol File:	123536-14-1.mol

(R)-3-Aminoquinuclidine dihydrochloride Chemical Properties

Melting point	>300 °C(lit.)
alpha	24 º (c=1, H2O)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated, Sonicated), Wat
form	Powder
color	White to beige
optical activity	[α]20/D +24°, c = 1 in H2O
Stability:	Hygroscopic
CAS DataBase Reference	123536-14-1(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38-R36/37/38
Safety Statements	26-38-36-S36-S26
WGK Germany	3
HS Code	29333990

MSDS Information

Provider	Language
SigmaAldrich	English

(R)-3-Aminoquinuclidine dihydrochloride Usage And Synthesis

Chemical Properties	(R)-3-Aminoquinuclidine dihydrochloride is White to beige powder
Uses	(R)-3-Aminoquinuclidine dihydrochloride is used in the preparation of serotonin type 3 (5-HT3) receptor antagonist as potential new drugs for the treatment of irritable bowel syndrome (IBS).
Uses	This diamine and its antipode are important building blocks in the synthesis of pharmaceuticals.

(R)-3-Aminoquinuclidine dihydrochloride Preparation Products And Raw materials

Raw materials	Sodium hydroxide-->Hydrochloric acid-->Tetrahydrofuran-->Toluene-->Potassium carbonate-->Palladium-->Sodium borohydride-->Sulfuryl chloride-->Sodium acetate trihydrate-->Ethyl chloroacetate-->Potassium tert-butoxide-->Ethyl bromoacetate-->Ethyl 4-piperidinecarboxylate-->L-1-Phenylethylamine-->Potassium ethylate
Preparation Products	(S)-3-Aminoquinuclidine dihydrochloride

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