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| 2-Chloro-4,6-dimethoxy-1,3,5-triazine Basic information |
| Product Name: | 2-Chloro-4,6-dimethoxy-1,3,5-triazine | | Synonyms: | CDMT;AKOS 89995;2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE;2-CHLORO-4,6-DIMETHOXY-TRIAZINE;Chlorodimethoxytriazine;2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE, 9 7%;2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE (CDMT);2-Chloro-4,6-dimethoxy-1 | | CAS: | 3140-73-6 | | MF: | C5H6ClN3O2 | | MW: | 175.57 | | EINECS: | 221-541-0 | | Product Categories: | Miscellaneous;Aromatics;Biochemistry;Coupling Reactions (Peptide Synthesis);Heterocycles;Miscellaneous Reagents;Starting Raw Materials & Intermediates;Peptide Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Triazines;TriazinesBuilding Blocks;bc0001 | | Mol File: | 3140-73-6.mol |
| 2-Chloro-4,6-dimethoxy-1,3,5-triazine Chemical Properties |
| Melting point | 71-74 °C (lit.) | | Boiling point | 99-100 °C (1 mmHg) | | density | 1.7917 (rough estimate) | | vapor pressure | 5.8Pa at 25℃ | | refractive index | 1.5870 (estimate) | | Fp | 99-100°C/1mm | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Chloroform, Methanol | | form | Crystalline Powder | | pka | 0.33±0.10(Predicted) | | color | White to almost white | | Water Solubility | insoluble | | BRN | 148988 | | InChIKey | GPIQOFWTZXXOOV-UHFFFAOYSA-N | | LogP | 2.105 at 25℃ | | CAS DataBase Reference | 3140-73-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37-36 | | RIDADR | UN3077 | | WGK Germany | 3 | | HS Code | 29339900 |
| 2-Chloro-4,6-dimethoxy-1,3,5-triazine Usage And Synthesis |
| Chemical Properties | white to almost white crystalline powder | | Uses | 2-Chloro-4,6-dimethoxy-1,3,5-triazine is used as a peptide coupling agent for the purification of peptides. It is used in the synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride through coupling with N-methylmorpholine in tetrahydrofuran. Further, it plays an important role in the production of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, through reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine. In addition to this, it is involved in the preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts through reaction with various tertiary amines. | | Uses | 2-Chloro-4,6-dimethoxy-1,3,5-triazine may be used in the following studies:- The specific labeling of streptavidin by the modular method for affinity labeling (MoAL).
- The preparation of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, via reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine.
- The preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts, via reaction with various tertiary amines.
- The synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride, via coupling with N-methylmorpholine in THF.
| | General Description | 2-Chloro-4,6-dimethoxy-1,3,5-triazine is a stable, yet highly reactive, peptide coupling agent. It is reported as useful coupling reagent for the purification of peptides. Catalytic amide-forming reactions of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported. Procedure for the preparation of multikilogram quantities of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported. |
| 2-Chloro-4,6-dimethoxy-1,3,5-triazine Preparation Products And Raw materials |
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