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| Acethydrazide Chemical Properties |
| Melting point | 58-68 °C (lit.) | | Boiling point | 129 °C/18 mmHg (lit.) | | density | 1.0968 (rough estimate) | | refractive index | 1.4264 (estimate) | | Fp | >230 °F | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | form | Moist Crystals and Chunks | | pka | 13.46±0.18(Predicted) | | color | White | | Water Solubility | soluble | | Sensitive | Hygroscopic | | BRN | 506165 | | InChIKey | OFLXLNCGODUUOT-UHFFFAOYSA-N | | CAS DataBase Reference | 1068-57-1(CAS DataBase Reference) | | NIST Chemistry Reference | Acetic acid, hydrazide(1068-57-1) | | EPA Substance Registry System | Acetic acid hydrazide (1068-57-1) |
| Hazard Codes | Xn,T | | Risk Statements | 22-36/38-68-40-25 | | Safety Statements | 26-36-45-36/37 | | RIDADR | 1759 | | WGK Germany | 1 | | RTECS | AI1225000 | | F | 3-8-10 | | TSCA | Y | | HazardClass | 6.1 | | PackingGroup | II | | HS Code | 29280090 | | Toxicity | LD50 oral in bird - wild: 42200ug/kg |
| Acethydrazide Usage And Synthesis |
| Description | Hydrazine, anhydrous appears as a colorless, fuming oily liquid with an ammonia-like odor. Flash point 99°F. Explodes during distillation if traces of air are present. Toxic by inhalation and by skin absorption. Corrosive to tissue. Produces toxic oxides of nitrogen during combustion.
| | Chemical Properties | White moist crystals and chunks | | Uses | Acetohydrazide is a metabolite of Isoniazid (I821450) an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. | | Uses | Acetic hydrazide is used as an antibiotic for the treatment of mycobacterium tuberculosis. It is also involved in the preparation of sunitinib b reacting with 5-fluoroisatin. Further, it inhibits mycolic acid biosynthesis. It serves as an important intermediate in organic synthesis such as nitric furosemide Long (nifuratrone) in medicine. | | Uses | Acethydrazide can be used in the synthesis of (E)-N′-(2-hydroxybenzylidene)acetohydrazide, an ONO pincer ligand. | | Definition | ChEBI: A carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group. | | Safety Profile | Poison by ingestion, subcutaneous, and intraperitoneal routes. Mutation data reported. Exposure can cause hemolysis and liver damage. See also PHENYLHYDRAZINE. When heated to decomposition it emits toxic fumes of NOX,. | | Purification Methods | Acetic hydrazide crystallises as needles from EtOH. It reduces NH3/AgNO3. [Beilstein 2 H 191, 2 IV 435.] |
| Acethydrazide Preparation Products And Raw materials |
| Raw materials | 2-N-BUTOXYETHYL METHACRYLATE-->Acetamide,N-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)--->NSC45006-->2-butanone (1-methylpropylidene)hydrazone-->Hydrazinecarboxylic acid, 2-acetyl-, 1,1-dimethylethyl ester (9CI)-->3,6-Dithia-1,8-octanediol-->Ethyl acetimidate hydrochloride-->Dibenzoylmethane-->Benzoylacetone-->Acetamide | | Preparation Products | 2-Mercapto-5-methyl-1,3,4-thiadiazole-->5-Methyl-1,3,4-oxadiazol-2(3H)-one-->FlubroMazolaM-->2-Amino-5-methyl-1,3,4-thiadiazole-->Ethyl 5-Methyl-1,3,4-thiadiazole-2-carboxylate-->Methylamine nitrate-->5-METHYL-1,3,4-OXADIAZOL-2-YLAMINE-->(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate |
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