Product

4-Pyrazoleboronic acid pinacol ester

CAS No.：269410-08-4

Other grades of this product :

4-Pyrazoleboronic acid pinacol ester Basic information

Product Name:	4-Pyrazoleboronic acid pinacol ester
Synonyms:	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole,min.97%;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, min. 97%;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole4-Pyrazoleboronic acid pinacol ester;4-Pyrazoleboronic acid pinacol ester,97%;4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyrazole;4-Pyrazoleboronic acid pinaol ester;1H-Pyrazole, 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS:	269410-08-4
MF:	C9H15BN2O2
MW:	194.04
EINECS:	629-131-7
Product Categories:	organic or inorganic borate;Pyrazole series;API intermediates;Boronic acid;OLED materials,pharm chemical,electronic
Mol File:	269410-08-4.mol

4-Pyrazoleboronic acid pinacol ester Chemical Properties

Melting point	142-146 °C (lit.)
Boiling point	335.4±15.0 °C(Predicted)
density	1.09±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO, Ethyl Acetate, Methanol
pka	13.36±0.50(Predicted)
form	Powder
color	Off-white to tan
Water Solubility	insoluble
InChIKey	TVOJIBGZFYMWDT-UHFFFAOYSA-N
CAS DataBase Reference	269410-08-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,F
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
Hazard Note	Irritant/Flammable
TSCA	No
HS Code	29331990

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

4-Pyrazoleboronic acid pinacol ester Usage And Synthesis

Chemical Properties	Off-white to tan powder
Uses	4-Pyrazoleboronic Acid Pinacol Ester is used in the preparation of Rho kinase (ROCK) inhibitors as wella s other biologically active compounds.
Uses	1H-Pyrazole-4-boronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. It is also used as reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors as well as other biologically active compounds.
Uses	Reagent used for Suzuki-Miyaura cross-couplings Ruthenium-catalyzed asymmetric hydrogenation Reagent used in preparation of inhibitors of many highly significant therapeutic enzymes and kinases containing the privileged scaffold pyrazole, including VEGF Aurora Rho (ROCK) Janus Kinase 2 (JAK) c-MET ALK S-nitrosoglutathione reductase CDC7 Acetyl-CoA carboxylase Prosurvival Bcl-2 protein Viral RNA-Dependent RNA polymerase Long Chain Fatty Acid Elongase 6 PI3 AKT Chk1 Protein Kinase B

4-Pyrazoleboronic acid pinacol ester Preparation Products And Raw materials

Preparation Products

1-{2-[(Tetrahydro-2H-pyran-2-yl)oxy]ethyl}-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-->1-Boc-pyrazole-4-boronic acid pinacol ester-->1-(2,2-difluoroethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-->4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole-->TERT-BUTYL 3-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)AZETIDINE-1-CARBOXYLATE-->4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-([2-(trimethylsilyl)ethoxy]methyl)-1H-pyrazole-->1-(2-Methoxyethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-->4-hydroxypyrazole-->1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-->1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester

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