Methyl thioglycolate

CAS No.：2365-48-2

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Methyl thioglycolate Basic information

Product Name:	Methyl thioglycolate
Synonyms:	MERCAPTOACETIC ACID METHYL ESTER;METG;METHYL THIOGLYCOLATE;METHYL THIOGLYCOLLATE;METHYL MERCAPTOACETATE;THIOGLYCOLIC ACID METHYL ESTER;mercapto-aceticacimethylester;Methanethiol, methoxy-
CAS:	2365-48-2
MF:	C3H6O2S
MW:	106.14
EINECS:	219-121-7
Product Categories:	2365-48-2
Mol File:	2365-48-2.mol

Methyl thioglycolate Chemical Properties

Melting point	-24 °C
Boiling point	42-43 °C/10 mmHg (lit.)
density	1.187 g/mL at 25 °C (lit.)
refractive index	n20/D 1.466(lit.)
Fp	86 °F
storage temp.	Store below +30°C.
solubility	40g/l
form	Liquid
pka	8.04±0.10(Predicted)
color	Clear colorless
Water Solubility	40 g/L (20 ºC)
Sensitive	Air Sensitive
BRN	506259
InChIKey	MKIJJIMOAABWGF-UHFFFAOYSA-N
CAS DataBase Reference	2365-48-2(CAS DataBase Reference)
NIST Chemistry Reference	Acetic acid, mercapto-, methyl ester(2365-48-2)
EPA Substance Registry System	Acetic acid, mercapto-, methyl ester (2365-48-2)

Safety Information

Hazard Codes	Xn,T
Risk Statements	10-20/22-36/37/38-25
Safety Statements	26-36/37-45-36/37/39-28A
RIDADR	UN 1992 3/PG 3
WGK Germany	1
RTECS	AI7350000
TSCA	Yes
HazardClass	3
PackingGroup	III
HS Code	29309070
Hazardous Substances Data	2365-48-2(Hazardous Substances Data)

MSDS Information

Provider	Language
Methyl mercaptoacetate	English
SigmaAldrich	English
ACROS	English
ALFA	English

Methyl thioglycolate Usage And Synthesis

Chemical Properties	CLEAR COLOURLESS LIQUID
Uses	Methyl Thioglycolate is an derivative of Thioglycolic Acid (T350760), an organic compound containing both a thiol and a carboxylic acid functional groups. Thioglycolic Acid and its derivatives are oft en used in organic synthesis as a nucleophile in thioglycolysis reactions and is also used as a S transfer agent for sulfonyl chloride synthesis. Methyl Thioglycolate have been studied for the its inf luence on neocarzinostatin activation and expression of DNA damage.
Uses	Methyl thioglycolate was used in the preparation of 3-carbomethoxy-4- oxotetrahydrothiopyran, 2- and 4-carbomethoxy-3-oxotetrahydrothiophene. It is used to prepare methyl thioglycolate and aminoethanethiol conjugated gold nanorods.
General Description	Methyl thioglycolate reacts with nonprotein component of the antitumor antibiotic neocarzinostatin to form 1:1 adduct. It reacts with isothiocyanate to form Rhodanine.

Methyl thioglycolate Preparation Products And Raw materials

Raw materials

Mercaptoacetic acid

Preparation Products

1-Benzothiophen-5-amine-->Rhodanine-3-acetic acid-->5-BROMO-4-METHOXYTHIOPHENE-3-CARBONYL CHLORIDE-->Methyl 3-amino-2-thiophenecarboxylate-->5-BROMO-4-METHOXYTHIOPHENE-3-CARBOXYLIC ACID-->5-CHLORO-4-METHOXYTHIOPHENE-3-CARBONYL CHLORIDE-->5-CHLORO-4-METHOXYTHIOPHENE-3-CARBOXYLIC ACID-->Thifensulfuron methyl-->4-Chlorothieno[3,2-d]pyrimidine-->Methyl 3-hydroxythiophene-2-carboxylate-->4-METHOXYTHIOPHENE-3-CARBOXAMIDE-->4-METHOXYTHIOPHENE-3-CARBOXYLIC ACID-->METHYL 7-AMINOTHIENO[2,3-B]PYRAZINE-6-CARBOXYLATE-->3-AMINO-5-(TERT-BUTYL)THIOPHENE-2-CARBOXAMIDE-->METHYL 4-METHOXYTHIOPHENE-3-CARBOXYLATE-->3-AMINO-6-METHYLTHIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE-->METHYL 3-CHLOROTHIOPHENE-2-CARBOXYLATE-->S-Methyl isovalerate-->4-METHYL-3-AMINO-2-(METHOXYCARBONYL)-4,5-DIHYDROTHIOPHENE-->METHYL 3-AMINO-5-(TERT-BUTYL)THIOPHENE-2-CARBOXYLATE-->METHYL 3-AMINO-6-METHYLTHIOPHENO[2,3-B]PYRIDINE-2-CARBOXYLATE-->3-CHLORO-4-METHYL-2-THIOPHENECARBOXYLIC ACID-->METHYL 3-CHLORO-4-METHYLTHIOPHENE-2-CARBOXYLATE-->Dimethyl 4-aminothiophene-2,3-dicarboxylate hydrochloride-->Methyl 3-amino-4-phenylthiophene-2-carboxylate-->3-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER-->3-AMINOTHIOPHENE-2-CARBOXAMIDE-->5-NITRO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID-->Methyl 3-amino-4-methylthiophene-2-carboxylate-->METHYL 4-OXOTETRAHYDROTHIOPHENE-3-CARBOXYLATE

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