2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite

CAS No.：102691-36-1

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2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite Basic information

Product Name:	2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite
Synonyms:	P-REAGENT;2-Cyanoethoxybis(N,N-diisopropylaMino)phosphine;Bis(diisopropylaMino)(2-cyano;N,N,N',N'-Tetrakis(1-Methylethyl)phosphorodiaMidous Acid 2-Cyanoethyl Ester;THERAPEUTIC GRADE PHOS REAGENT;2-Cyanoethyl N,N,N',N'-tetra(prop-2-yl)phosphorodiamidoite;2-Cyanoethyl N,N,N',N'-tetrakis(isopropyl)phosphorodiamidite;β-Cyanoethyl-N,N,N`,N`-tertraisopropylphosphorodiaMidite
CAS:	102691-36-1
MF:	C15H32N3OP
MW:	301.41
EINECS:	600-337-9
Product Categories:	OLED materials,pharm chemical,electronic;Building Blocks;Chemical Synthesis;Organic Building Blocks;Phosphoramidites;Phosphorus Compounds;Biochemistry;Nucleosides, Nucleotides & Related Reagents;Phosphorylating and Phosphorothioating Agents;Protecting Agents, Phosphorylating Agents & Condensing Agents;Regant series;Nucleic acids;Phosphorylating and Phosphitylating Agents
Mol File:	102691-36-1.mol

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite Chemical Properties

Boiling point	100 °C0.5 mm Hg(lit.)
density	0.949 g/mL at 25 °C(lit.)
refractive index	n20/D 1.470(lit.)
Fp	141 °F
storage temp.	-20°C
form	liquid
pka	6.78±0.70(Predicted)
color	colorless
Sensitive	moisture sensitive, store cold
BRN	3590103
Stability:	Explodes When Heated
InChIKey	RKVHNYJPIXOHRW-UHFFFAOYSA-N
LogP	4.04 at 20℃
CAS DataBase Reference	102691-36-1(CAS DataBase Reference)
EPA Substance Registry System	Phosphorodiamidous acid, tetrakis(1-methylethyl)-, 2-cyanoethyl ester (102691-36-1)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	5-36/37/38-42/43-36/38
Safety Statements	3-26-36-24/25-23-45-36/37
RIDADR	UN 1993 3/PG 3
WGK Germany	3
F	10-21-34
Hazard Note	Irritant/May Explode on Heating
HazardClass	8
PackingGroup	I
HS Code	29299000

MSDS Information

Provider	Language
SigmaAldrich	English

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite Usage And Synthesis

Chemical Properties	Clear to Cloudy Colourless Liquid
Uses	Reagent for synthesizing phosphitylated nucleotides.1
Uses	2-Cyanoethyl N,N,N′,N′-tetraisopropylphosphordiamidite was used: in preparation of prosphoramidite reagent, required for synthesis of 12-mer oligodeoxynucleotide as phosphorylating agent in synthesis of 1,2-diacyl-sn-glycerophosphatidylserine in situ preparation of deoxyribonucleoside phosphoramidites in preparation of 2′-deoxy-2′-fluoro-3′-O-(β-cyanoethyl-N,N-diisopropylphosphoramidic)-5′-O-(4-methoxytrityl)-4′-thio-β-D-arabinouridine and 1-(3-O-(β-cyanoethyl-N,N-diisopropylphosphoramidic)-2-deoxy-2-fluoro-5-O-(4,4′-dimethoxytrityl)-4-thio-β-D-arabinofuranosyl)-thymine as reagent for synthesizing phosphitylated nucleotides

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite Preparation Products And Raw materials

Raw materials	5'-AMINO-5'-DEOXYTHYMIDINE-->BIS(DIISOPROPYLAMINO)CHLOROPHOSPHINE-->2-CYANOETHYL PHOSPHORODICHLORIDITE-->Diisopropylamine
Preparation Products	Ceftibuten-->anionic starch-->DMT-DCYTIDINE (N6-BENZOYL) CYANOETHYL PHOSPHORAMIDITE)-->N4-(DIMETHYLAMINO)METHYLENE)-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE

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