| STIRIPENTOL Basic information |
| Product Name: | STIRIPENTOL |
| Synonyms: | Diacomit;(RS)-(E)-4,4-dimethyl-1-[3,4(methylenedioxy)-phenyl]-1-penten-3-ol;1-(1,3-BENZODIOXOL-5YL)-4,4-DIMETHYL-1-PENTEN-3-OL;STIRIPENTOL;1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-o;4,4-dimethyl-1-(3,4-methylenedioxyphenyl)-1-penten-3-o;4,4-dimethyl-1-(3,4-methylenedioxyphenyl)-1-penten-3-ol;bcx2600 |
| CAS: | 49763-96-4 |
| MF: | C14H18O3 |
| MW: | 234.29 |
| EINECS: | 256-480-9 |
| Product Categories: | Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 49763-96-4.mol |
| STIRIPENTOL Chemical Properties |
| Melting point | 73-74°C |
| Boiling point | 365.4±11.0 °C(Predicted) |
| density | 1.139±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: ≥20mg/mL |
| pka | 14.45±0.20(Predicted) |
| form | powder |
| color | white to beige |
| InChIKey | IBLNKMRFIPWSOY-FNORWQNLSA-N |
| CAS DataBase Reference | 49763-96-4 |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
| RTECS | SB3393000 |
| MSDS Information |
| STIRIPENTOL Usage And Synthesis |
| Description | Stiripentol is a third-generation antiepileptic compound. It is a positive allosteric modulator of GABAA receptors, potentiating GABA-mediated activation to a greater extent in receptors expressing α3 subunits and to a lower extent in those containing β1 or ε subunits. It also inhibits GABA reuptake in vitro and increases the release of GABA in neonatal rat hippocampal slices. Stiripentol (500 μM) inhibits lactate dehydrogenase (LDH), blocking both lactate-to-pyruvate and pyruvate-to-lactate conversions by human LDH1 and LDH5. Formulations containing stiripentol have been used in the adjunctive treatment of seizures associated with Dravet syndrome. |
| Chemical Properties | White Solid |
| Uses | An antiepileptic drug |
| Uses | Stiripentol is an epilepsy drug, it has been used as co-therapy for treatment of epilepsy. |
| Uses | Stiripentol has been used in pharmacokinetic analysis and as a reference standard in fluorescence spectra analysis. |
| Biochem/physiol Actions | Anti-convulsant drug |
| STIRIPENTOL Preparation Products And Raw materials |
| Preparation Products | 1-(3,4-METHYLENEDIOXY-PHENYL)-4,4-DIMETHYL-PENT-1-EN-3-ONE |
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