(R)-(+)-1-Phenylethylamine

CAS No.：3886-69-9

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(R)-(+)-1-Phenylethylamine Basic information

Product Name:	(R)-(+)-1-Phenylethylamine
Synonyms:	(1R)-1-PHENYLETHANAMINE;(1R)-1-PHENYLETHYLAMINE;(+)-D-ALPHA-METHYLBENZYLAMINE;D(+)-ALPHA-METHYLBENZYLAMINE;D-ALPHA-METHYLBENZYLAMINE;D-(+)-ALPHA-PHENYLETHYLAMINE;D-ALPHA-PHENYLETHYLAMINE;D-(+)-A-METHYLBENZYLAMINE
CAS:	3886-69-9
MF:	C8H11N
MW:	121.18
EINECS:	223-423-4
Product Categories:	Amines;Aromatics;chiral;Amines (Chiral);Analytical Chemistry;Chiral Reagents;Asymmetric Synthesis;Chiral Building Blocks;e.e. / Absolute Configuration Determination (NMR);Enantiomer Excess & Absolute Configuration Determination;for Resolution of Acids;Optical Resolution;Synthetic Organic Chemistry;Chiral Compound;Benzene derivatives
Mol File:	3886-69-9.mol

(R)-(+)-1-Phenylethylamine Chemical Properties

Melting point	-10 °C
alpha	40 º (neat)
Boiling point	187-189 °C(lit.)
density	0.952 g/mL at 20 °C(lit.)
vapor pressure	0.5 mm Hg ( 20 °C)
refractive index	n20/D 1.526(lit.)
Fp	175 °F
storage temp.	2-8°C
solubility	40g/l
form	Liquid
pka	9.04±0.10(Predicted)
color	Clear colorless
PH	>7 (40g/l, H2O, 20℃)
optical activity	[α]23/D +38°, neat
Water Solubility	40 g/L (20 ºC)
Sensitive	Air Sensitive
Merck	14,6026
BRN	2410916
InChIKey	RQEUFEKYXDPUSK-SSDOTTSWSA-N
LogP	1.31-1.49 at 25℃
CAS DataBase Reference	3886-69-9(CAS DataBase Reference)
NIST Chemistry Reference	Benzenemethanamine, «alpha»-methyl-, (R)-(3886-69-9)
EPA Substance Registry System	Benzenemethanamine, .alpha.-methyl-, (.alpha.R)- (3886-69-9)

Safety Information

Hazard Codes	C
Risk Statements	21/22-34
Safety Statements	26-28-36/37/39-45-28A-27
RIDADR	UN 2735 8/PG 2
WGK Germany	3
F	3-10-23-34
Autoignition Temperature	355 °C DIN 51794
TSCA	Yes
HazardClass	8
PackingGroup	III
HS Code	29214980

MSDS Information

Provider	Language
(R)-(+)-1-Phenylethylamine	English
ACROS	English
SigmaAldrich	English
ALFA	English

(R)-(+)-1-Phenylethylamine Usage And Synthesis

Chemical Properties	Colorless to light yellow liqui
Uses	(R)-(+)-1-Phenylethylamine is a chiral amine used for the determination of the enantiomeric purity of acids.
Uses	(R)-(+)-a-Methylbenzylamine also known as (R)-(+)-1-Phenylethylamine may be used in resolution of a chiral arylalkylamine involving high-conversion enantioselective condensation with capric acid followed by hydrolysis to yield corresponding (R)-(+)-amide.
Definition	ChEBI: The (R)-enantiomer of 1-phenylethanamine.
General Description	(R)-(+)-α-Methylbenzylamine is a chiral amine.
Flammability and Explosibility	Nonflammable
Purification Methods	Dissolve the amine in toluene, dry over NaOH and distil; fraction boiling at 187-188o/atm is collected. Store it under N2 to avoid forming the carbamate and urea. Similarly for the S-(-) enantiomer [2627-86-3]. [Ingersoll Org Synth Coll Vol II 503 1943, Robinson & Snyder Org Synth Coll Vol III 717 1955, Beilstein 12 IV 2424, 2425.]

(R)-(+)-1-Phenylethylamine Preparation Products And Raw materials

Preparation Products

(S)-3-Aminoquinuclidine dihydrochloride-->(R)-(+)-2-Methyl-2-propanesulfinamide-->(R)-(+)-1,1'-Bi-2-naphthol-->(S)-(-)-1,1'-Bi-2-naphthol-->(R)-(+)-BORNYLAMINE-->(R,R)-(+)-BIS(ALPHA-METHYLBENZYL)AMINE HYDROCHLORIDE-->(+)-Bis[(R)-1-phenylethyl]amine-->DL-alpha-Methylbenzylamine-->(R)-PIPERAZINE-2-CARBOXYLIC ACID-->(R)-(+)-(3,4-Dimethoxy)benzyl-1-phenylethylamine-->(S)2-(2-Oxo pyrrolidin-1-yl)-Butiric acid methyl ester-->(R)-(+)-N-(1-PHENYLETHYL)PHTHALAMIC ACID-->(R)-(+)-N,ALPHA-DIMETHYLBENZYLAMINE-->(R)-(+)-N-Benzyl-1-phenylethylamine-->(METHYLTHIO)ACETIC ACID

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