Other grades of this product :
| Product Name: | Mildronate dihydrate | | Synonyms: | 3-(2,2,2-Trimethylhydrazinium)propionate dihydrate;Mildronate dihydrate;Hydrazinium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, inner salt;Meldonium;Mildronate dihydrate, >=99%;Mildronate (hydrate);3-(1,1,1-Trimethylhydrazin-1-ium-2-yl)propanoate dihydrate;Meldonium dihydrate | | CAS: | 86426-17-7 | | MF: | C6H14N2O2.2H2O | | MW: | 182.218 | | EINECS: | 695-494-3 | | Product Categories: | Cardiovascular APIs;Inhibitors | | Mol File: | 86426-17-7.mol |
| Mildronate dihydrate Chemical Properties |
| Melting point | 85 - 87°C | | storage temp. | 2-8°C | | solubility | H2O: >40mg/mL | | form | powder | | color | white to off-white | | InChIKey | JFWLFLLRLZSBRA-UHFFFAOYSA-N |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 |
| Mildronate dihydrate Usage And Synthesis |
| Appearance | white to off-white powder | | Description | Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.Mildronate (40 μM) inhibits the reaction of γ-butyrobetaine hydroxylase with γ-butyrobetaine with Km and Vmax of 36.8 μM and 0.08 nmol/min/mg protein, respectively. | | Uses | Meldonium dihydrate has been used as an anti-ischemic agent to evaluate its protective effects on Ischemia-reperfusion (I/R) in chick embryos. | | Biochem/physiol Actions | Meldonium is an Inhibitor of γ-butyrobetaine hydroxylase (BBOX) a key enzyme in the synthesis of carnitine. |
| Mildronate dihydrate Preparation Products And Raw materials |
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