Ethoxyacetic acid

Ethoxyacetic acid
  • CAS No.:627-03-2
Other grades of this product :
Ethoxyacetic acid Basic information
Product Name:Ethoxyacetic acid
Synonyms:2-ethoxyacetate;2-Ethoxyacetic acid;2-ethoxyaceticacid;Aceticacid,ethoxy-;ethoxy-aceticaci;Ethoxyethanoicacid;Glycolic ethyl ether;Ethoxyacetic acid,98%
CAS:627-03-2
MF:C4H8O3
MW:104.1
EINECS:210-978-2
Product Categories:Building Blocks;C1 to C5;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks;Acetics acid and esters;Organic acids
Mol File:627-03-2.mol
Ethoxyacetic acid Chemical Properties
Boiling point 97-100 °C/11 mmHg (lit.)
density 1.102 g/mL at 25 °C (lit.)
refractive index n20/D 1.419(lit.)
Fp 208 °F
storage temp. 2-8°C
form Liquid
pka3.65(at 18℃)
color Clear colorless to light yellow
Water Solubility soluble
BRN 1743037
Stability:Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference627-03-2(CAS DataBase Reference)
NIST Chemistry ReferenceAcetic acid, ethoxy-(627-03-2)
EPA Substance Registry SystemEthoxyacetic acid (627-03-2)
Safety Information
Hazard Codes C,Xi
Risk Statements 34
Safety Statements 26-36/37/39-45
RIDADR UN 3265 8/PG 2
WGK Germany 3
RTECS AH3600000
Hazard Note Irritant
TSCA Yes
HazardClass 8
PackingGroup III
HS Code 29189900
MSDS Information
ProviderLanguage
O-Ethylglycolic acid English
ACROS English
SigmaAldrich English
ALFA English
Ethoxyacetic acid Usage And Synthesis
Chemical Propertiesliquid
UsesEthoxyacetic acid is used to evaluate toxicity in embryonic stem cell test in mice. It finds application as a biomarker of exposure to alkyl-substituted ethylene glycols and other aliphatic ethers. It is used as a precursor to prepare ethoxy-acetic acid ethoxymethyl ester.
General DescriptionLiquid.
Air & Water ReactionsWater soluble.
Reactivity ProfileAn ether and organic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat.
Health HazardACUTE/CHRONIC HAZARDS: Ethoxyacetic acid is corrosive.
Fire HazardEthoxyacetic acid is combustible.
Biochem/physiol ActionsEthoxyacetic acid induces testicular toxicity in rats in vivo .
Safety ProfileExperimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

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