4-(Trifluoromethoxy)benzyl bromide

CAS No.：50824-05-0

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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4-(Trifluoromethoxy)benzyl bromide Basic information

Uses

Product Name:	4-(Trifluoromethoxy)benzyl bromide
Synonyms:	4-(TRIFLUOROMETHOXY)BENZYL BROMIDE;ALPHA-BROMO-4-(TRIFLUOROMETHOXY)TOLUENE;1-(BROMOMETHYL)-4-(TRIFLUOROMETHOXY)BENZENE;TIMTEC-BB SBB006578;P-TritluromethoxybenzylBromide;4-(Trifluoromethoxy)benzyl;4-(Trifluoromethoxy)benzyl bromide 97%;4-(Trifluoromethoxy)benzylbromide97%
CAS:	50824-05-0
MF:	C8H6BrF3O
MW:	255.03
EINECS:
Product Categories:	Aromatic Halides (substituted);Miscellaneous;Ethers;Organic Building Blocks;Oxygen Compounds;Trifluoro-methoxy-benzene series
Mol File:	50824-05-0.mol

4-(Trifluoromethoxy)benzyl bromide Chemical Properties

Melting point	22-24°C
Boiling point	82-84 °C10 mm Hg(lit.)
density	1.594 g/mL at 25 °C(lit.)
refractive index	n20/D 1.48(lit.)
Fp	202 °F
storage temp.	Refrigerated.
form	Liquid or Low Melting Solid
Specific Gravity	1.594
color	Clear faintly yellow
Sensitive	Lachrymatory
BRN	2521451
CAS DataBase Reference	50824-05-0(CAS DataBase Reference)

Safety Information

Hazard Codes	C
Risk Statements	34
Safety Statements	26-27-28-36/37/39-45
RIDADR	UN 3265 8/PG 2
WGK Germany	3
Hazard Note	Corrosive/Lachrymatory
HazardClass	8
PackingGroup	III
HS Code	29093090

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

4-(Trifluoromethoxy)benzyl bromide Usage And Synthesis

Uses	4-Trifluoromethoxybenzyl Bromide is a useful synthetic intermediate. It is used to prepare (nitro)[(trifluoromethoxy)benzyloxy]dihydroimidazo[2,1-b][1,3]oxazines with antitubercular activities. It is also used to synthesize tetrahydronaphthalenols with anti-allergic activities.
Chemical Properties	Colorless to light yellow liqui
Uses	4-(Trifluoromethoxy)benzyl bromide may be used in the synthesis of bioreductive drug, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
General Description	Polymerizations of 4-(trifluoromethoxy)benzyl bromide, via Friedel-Crafts polymerization using aluminum chloride as a catalyst has been reported.

4-(Trifluoromethoxy)benzyl bromide Preparation Products And Raw materials

Preparation Products

4-(Trifluoromethyl)phenylacetic acid-->4-(Trifluoromethoxy)benzoic acid

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