Other grades of this product :
| Bromisoval Basic information |
| Product Name: | Bromisoval | | Synonyms: | RARECHEM AX KI 5046;1-(2-BROMOISOVALERYL)UREA;A-(BROMOISOVALERYL)UREA;ALPHA(BROMOISOVALERYL)UREA;LABOTEST-BB LT00134620;BROMOVALERYLUREA;BROMOISOVALERYLUREA;BROMO-ISO-VALERYLUREA (ALPHA) | | CAS: | 496-67-3 | | MF: | C6H11BrN2O2 | | MW: | 223.07 | | EINECS: | 207-825-7 | | Product Categories: | API | | Mol File: | 496-67-3.mol |
| Bromisoval Chemical Properties |
| RTECS | YS3150000 | | Toxicity | LD50 in male mice (mmoles/kg): 3.25 i.p. (Mrongovius) |
| Bromisoval Usage And Synthesis |
| Chemical Properties | White Solid | | Originator | Bromisovalum,Linhai Duqiao Fine
Chemical Factory | | Uses | 2-Bromo-3-methylbutyrylurea is a hypnotic and sedative drug marketed over the counter in Asian under various brand names. | | Definition | ChEBI: An N-acylurea that is urea in which one of the hydrogens is replaced by a 2-bromo-3-methybutanoyl group. | | Manufacturing Process | A mixture of 2 kg 2-bromoisovalerylbromide and 1 kg dry urea is heated at
70°C. Then to the reaction mixture is added sodium hydrogen carbonate. 2-
Bromo-3-methylbutyrylurea is recrystallized from toluene or water, melting
point 149°C. | | Brand name | Bromural (Knoll). | | Therapeutic Function | Sedative, Hypnotic | | World Health Organization (WHO) | Bromisoval is a monureide sedative of long standing. It remains
available in several countries. However, it releases the bromide ion and prolonged
usage can result in chronic bromide accumulation and intoxication. | | Safety Profile | Moderately toxic by
ingestion. Human systemic effects by
ingestion: nausea or vomiting, and coma. A
sedative and hypnotic agent. When heated
to decomposition it emits very toxic fumes
of Brand NOx | | Purification Methods | Crystallise it from aqueous EtOH or toluene, and dry it in air. [Beilstein 3 H 63, 3 I 29, 3 II 51, 3 III 123, 3 IV 117.] |
| Bromisoval Preparation Products And Raw materials |
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