Other grades of this product :
| Racecadotril Chemical Properties |
| Melting point | 89°C | | Boiling point | 574.5±50.0 °C(Predicted) | | density | 1.206 | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMSO: ≥44mg/mL | | pka | 13.63±0.46(Predicted) | | form | powder | | color | white to tan | | Merck | 14,8090 | | InChIKey | ODUOJXZPIYUATO-UHFFFAOYSA-N | | CAS DataBase Reference | 81110-73-8(CAS DataBase Reference) |
| Hazard Codes | Xn,N | | Risk Statements | 22-50/53 | | Safety Statements | 60-61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | RTECS | MB7606872 | | HS Code | 29309090 |
| Racecadotril Usage And Synthesis |
| Description | Racecadotril (also called acetorphan) is a kind of antidiarrheal drug acting as a peripherally acting enkephalinase inhibitor. It has an antisecretory effect, reducing the secretion of water and electrolytes into the intestine. Racecadotril is a protodrug, being broken down into the active ingredient, thiorphan. Thiorphan exerts its inhibitory effect on enkephalinase, reducing the amount of secreted water produced by the intestines. In this case, the body loses less fluid, and the symptoms of diarrhea can be alleviated.
| | References | https://en.wikipedia.org/wiki/Racecadotril
https://patient.info/medicine/racecadotril-for-acute-diarrhoea-hidrasec
| | Description | Acetorphan is an orally-active enkephalinase inhibitor introduced in 1993 for the
treatment of acute diarrhea in adults.It displays antidiarrheal activity via a purely
antisecretory mechanism without inhibiting intestinal transit. Acetorphan acts as rapidly as
loperamide, a classical mu opiate receptor agonist that exhibits its antidiarrheal effect via an
antitransit mechanism, without producing constipation or other side effects. The novel
mechanism of action may render acetorphan potentially useful in the management of
infectious diarrhea. | | Description | Racecadotril is an enkephalinase inhibitor that prevents the degradation of endogenous opioids. It demonstrates antidiarrheal activity by reducing hypersecretion of water and electrolytes into the intestinal lumen. Racecadotril is a pro-drug that is metabolized in vivo into the active compound, thiorphan . | | Chemical Properties | White Solid | | Originator | Bioprojet (France) | | Uses | Antidiarrheal; enkephalinase inhibitor, reducing the amount of water and electrolytes into the intestine. | | Brand name | Tiorfan | | Clinical Use | Treatment of acute diarrhoea | | Drug interactions | Potentially hazardous interactions with other drugs
None known | | Metabolism | Quickly metabolised by hydrolysis to active metabolite,
thiorphan. Racecadotril is eliminated as active and
inactive metabolites. Elimination is mainly via the renal
route, and to a much lesser extent via the faecal route
(around 8%). The pulmonary route is not significant (less
than 1% of the dose). |
| Racecadotril Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye