SELEXIPAG interMediate

CAS No.：475086-75-0

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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SELEXIPAG interMediate Basic information

Product Name:	SELEXIPAG interMediate
Synonyms:	SELEXIPAG interMediate;4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]-1-Butanol;Selexipag intermediates;1-Butanol, 4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]-;1-Butanol, 4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]-;4-[(5,6-Diphenylpyrazinyl)(1-methylethyl)amino]-1-butanol;-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]-1-Butanol;4-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol
CAS:	475086-75-0
MF:	C23H27N3O
MW:	361.48
EINECS:	813-799-3
Product Categories:	selexipag;non-prostanoid prostacyclin (PGI2) receptor agonist
Mol File:	475086-75-0.mol

SELEXIPAG interMediate Chemical Properties

Melting point	68 - 71°C
Boiling point	514.4±50.0 °C(Predicted)
density	1.112±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly)
pka	15.05±0.10(Predicted)
form	Solid
color	Pale Yellow to Light Yellow

Safety Information

MSDS Information

SELEXIPAG interMediate Usage And Synthesis

Uses

4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]-1-butanol is a diphenylpyrazine derivative which belongs to a class of prostacyclin receptor agonists. It is an impurity of Selexipag (S253150) that is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.

Application

Selexipag interMediate is a synthetic organic compound that is used as an intermediate in the synthesis of oxychloride. It is an oxychloride with a nucleophilic substitution reaction. The reaction proceeds selectively at the phosphorus atom and gives high yield. The reactivity of 4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butan-1-ol is enhanced by the use of n butanol, which also acts as a solvent for the reaction. The product can be purified by filtration or recrystallization from hexane with piperazine as a reagent.

SELEXIPAG interMediate Preparation Products And Raw materials

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