Levosulpiride

CAS No.：23672-07-3

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

View the full Disclaimer

Other grades of this product :

Levosulpiride Basic information

Product Name:	Levosulpiride
Synonyms:	(s)-(-)-n-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide;(s)-(-)-o-anisamid;(S)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide;China (S)-(-)-Sulpiride;Levosulpiride, (S)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide;S-(-)-Sulpiride，Levobren，Levopraid;(s)-(-)-n-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide 5-(aminosulfonyl)-n-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-benzamid ( s-(-)-benzamid;rv-12309 s-(-)-n-(1-ethyl-2-pyrrolidinomethyl)-2-methoxy-5-sulfamoylebenzamide
CAS:	23672-07-3
MF:	C15H23N3O4S
MW:	341.43
EINECS:	233-599-4
Product Categories:	Dopamine receptor;API;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Other APIs;Pharmaceuticals;Sulfur & Selenium Compounds;Chiral Reagents
Mol File:	23672-07-3.mol

Levosulpiride Chemical Properties

Melting point	183-186 °C(lit.)
density	1.236±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	9.98±0.60(Predicted)
form	neat
color	White to Off-White
Merck	14,8989
InChIKey	BGRJTUBHPOOWDU-NSHDSACASA-N
CAS DataBase Reference	23672-07-3(CAS DataBase Reference)

Safety Information

RIDADR	3077
WGK Germany	3
RTECS	BZ3400100
HS Code	29350090
Toxicity	LD50 oral in rabbit: > 1500mg/kg

MSDS Information

Provider	Language
SigmaAldrich	English

Levosulpiride Usage And Synthesis

Chemical Properties	White Solid
Uses	dopamine receptor antagonists
Uses	Dopamine D2 and D3-receptor antagonist. Antipsychotic; antidepressant; antiemetic.
Uses	(S)-(?)-Sulpiride was used to study the effect of dopamine D₂ receptor function on activation of KCNQ potassium channels¹⁰ and on depression-like behavior in ovariectomized female rats.¹¹
Definition	ChEBI: An optically active form of sulpiride having (S)-configuration. The active enantiomer of the racemic drug sulpiride. Selective D2-like dopamine antagonist (Ki values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 muM at D2, D3, D4, 1 and D5 receptors respectively).
General Description	(S)-(?)-Sulpiride is a levorotatory enantiomer of sulpiride, which shows greater central antidopaminergic activity, antiemetic and antidyspeptic effects. It is also used as a therapeutic drug for the treatment of depression and somatoform disorders.
Biological Activity	Active enantiomer. Selective D 2 -like dopamine antagonist (K i values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 μ M at D 2 , D 3 , D 4 , D 1 and D 5 receptors respectively).
Biochem/physiol Actions	(S)-(?)-Sulpiride or Levosulpiride blocks the inhibitory enteric D2 receptors (neuronal and muscular). It has prokinetic activity and is effective in the treatment of functional dyspepsia and gastroparesis in insulin-dependent diabetes mellitus patients.7,8 Since dopamine controls human sexual function, (S)-(?)-Sulpiride is reportedly effective in treatment of erectile dysfunctions.9

Levosulpiride Preparation Products And Raw materials

Raw materials

Ethanol-->Sodium hydroxide-->Lithium Aluminum Hydride-->L-Proline-->L(+)-Tartaric acid-->Methyl benzoate-->2-(Aminomethyl)-1-ethylpyrrolidine-->Sulpiride-->(S)-2-(Aminomethyl)-1-ethylpyrrolidine

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873