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| N-Boc-cadaverine Basic information |
| N-Boc-cadaverine Chemical Properties |
| Boiling point | 309.2±25.0 °C(Predicted) | | density | 0.972 g/mL at 20 °C(lit.) | | refractive index | n20/D 1.460 | | Fp | 109 °C | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | pka | 12.91±0.46(Predicted) | | form | Oil | | color | Yellow | | BRN | 3603658 | | InChIKey | DPLOGSUBQDREOU-UHFFFAOYSA-N | | CAS DataBase Reference | 51644-96-3(CAS DataBase Reference) |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 2735 8/PG 3 | | WGK Germany | 3 | | F | 10-34 | | HazardClass | 8 | | PackingGroup | Ⅲ | | HS Code | 2924190090 |
| N-Boc-cadaverine Usage And Synthesis |
| Description | tert-Butyl (5-aminopentyl)carbamate can be used as a PROTAC linker in the synthesis of PROTACs. tert-Butyl (5-aminopentyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine. | | Uses | Some of the reported applications of N-Boc-cadaverine include:- Synthesis of of a supermacrocycle that self-assemble to form organic nanotubes.
- Preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye.
- Synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).
| | Uses | N-Boc-cadaverine is an intermediate in the synthesis of derivative of the folic acid antagonist Methotrexate (M260675) used in the study of membrane-associated folate transporters from L1210 cells. |
| N-Boc-cadaverine Preparation Products And Raw materials |
| Raw materials | Carbamic acid, [5-[[(1,1-dimethylethoxy)carbonyl]amino]pentyl]-, phenylmethyl ester (9CI)-->Carbamic acid, (4-cyanobutyl)-, 1,1-dimethylethyl ester (9CI)-->Carbamic acid, N-(5-amino-5-oxopentyl)-, 1,1-dimethylethyl ester-->(5-Azidopentyl)carbaMic acid tert-butyl ester-->5-(BOC-AMINO)-1-PENTANOL-->Boc-5-aminopentanoic acid-->5-AMINOVALERIC ACID-->1,5-Diaminopentane-->Di-tert-butyl dicarbonate-->tert-Butyl phenyl carbonate-->1,5-DIAMINOPENTANE DIHYDROCHLORIDE-->2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile | | Preparation Products | Carbamic acid, N,N'-1,5-pentanediylbis-, C,C'-bis(1,1-dimethylethyl) ester |
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