Product

C-(1H-INDOL-5-YL)-METHYLAMINE

CAS No.：81881-74-5

Other grades of this product :

C-(1H-INDOL-5-YL)-METHYLAMINE Basic information

Product Name:	C-(1H-INDOL-5-YL)-METHYLAMINE
Synonyms:	5-(aminomethyl)-indol;INDOLE-5-METHYLAMINE;C-(1H-INDOL-5-YL)-METHYLAMINE;(1H-INDOL-5-YL)METHANAMINE;(1H-Indol-5-yl)methylamine;5-(AMINOMETHYL)INDOLE;((Indol-5-yl)Methyl)aMine;1-(1H-Indol-5-yl)MethanaMine
CAS:	81881-74-5
MF:	C9H10N2
MW:	146.19
EINECS:
Product Categories:	Amines;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;pharmacetical;Building Blocks;Heterocyclic Building Blocks;Indoles;Building Blocks;C7 to C9;Chemical Synthesis;Heterocyclic Building Blocks
Mol File:	81881-74-5.mol

C-(1H-INDOL-5-YL)-METHYLAMINE Chemical Properties

Melting point	114-122 °C
Boiling point	335.6±17.0 °C(Predicted)
density	1.199±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	17.07±0.30(Predicted)

Safety Information

Hazard Codes	Xn
Risk Statements	22-36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	NL4461500

MSDS Information

Provider	Language
SigmaAldrich	English

C-(1H-INDOL-5-YL)-METHYLAMINE Usage And Synthesis

Uses	5-(AMinoMethyl)indole has been used as reactant for preparation of:• and HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p751•
Uses	5-(Aminomethyl)indole is used in the synthesis of Vigabatrin (V253000) bioisosteres as inhibitors of γ-aminobutyric acid aminotransferase (GABA-AT) inhibitors.
Uses	Reactant for preparation of: HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p75 Inhibitors of Gli1-mediated transcription in the Hedgehog pathway SCIO-469-like compounds for the inhibition of p38 MAP kinase 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles as protein kinase c theta (PKC θ) inhibitors Non-covalent thrombin inhibitors

C-(1H-INDOL-5-YL)-METHYLAMINE Preparation Products And Raw materials

Raw materials	Lithium Aluminum Hydride-->Sodium cyanide-->Ethylenediamine-->Copper(I) Cyanide-->N-Methyl-2-pyrrolidone-->5-Bromoindole
Preparation Products	5-Cyanoindole

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