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| Gimeracil Basic information |
| Gimeracil Chemical Properties |
| Melting point | 274 °C | | Boiling point | 255.1±40.0 °C(Predicted) | | density | 1.56±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | Soluble in DMSO (up to 5 mg/ml). | | pka | 4.50±1.00(Predicted) | | form | solid | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | | InChIKey | ZPLQIPFOCGIIHV-UHFFFAOYSA-N | | CAS DataBase Reference | 103766-25-2(CAS DataBase Reference) |
| Safety Statements | 24/25 | | HS Code | 29337900 |
| Gimeracil Usage And Synthesis |
| Description | Gimeracil (103766-25-2) is a dihydropyrimidine dehydrogenase (DPD) inhibitor.? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Gimeracil is used along with 5-FU or Tegafur to prolong circulating concentrations of the drugs.1,2? Gimeracil has also been shown to act as a radiosensitizer via inhibition of homologous recombination in the repair of DNA double strand breaks.3 | | Chemical Properties | Off-White Solid | | Uses | Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair. | | Uses | Gimeracil is an antitumor agent. Gimeracil is a potent inhibitor of dihydropyrimidine dehydrogenase (DPD). | | Uses | Antitumor agent. A potent inhibitor of dihydropyrimidine dehydrogenase (DPD) | | References | 1) Diasio (1999)?Clinical implications of dihydropyrimidine dehydrogenase inhibition; Oncology(Williston Park),?13?17
2) Kobayakawa and Kojima (2011),?Tegafur/gimeracil/oteracil (S-1) approved for the treatment of advanced gastric cancer in adults when given in combination with cisplatin: a review comparing it with other fluoropyrimidine-based therapies; Onco. Targets Ther.,?4?193
3) Sakata?et al.?(2011),?Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination; Cancer Sci.,?102?1712 |
| Gimeracil Preparation Products And Raw materials |
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