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| Dimethylamine hydrochloride Basic information |
| Dimethylamine hydrochloride Chemical Properties |
| Melting point | 170-173 °C(lit.) | | Boiling point | 95.79°C (rough estimate) | | density | 0.8949 (rough estimate) | | vapor pressure | <0.1 hPa (25 °C) | | refractive index | 1.4202 (estimate) | | storage temp. | Store below +30°C. | | solubility | H2O: soluble0.5g/10 mL | | form | Crystalline Powder or Crystals | | color | White to off-white | | PH | 5 (100g/l, H2O, 20℃) | | Water Solubility | 3000 g/L (20 ºC) | | Sensitive | Hygroscopic | | Merck | 14,3228 | | BRN | 3589311 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | InChIKey | IQDGSYLLQPDQDV-UHFFFAOYSA-N | | LogP | -3.28 | | CAS DataBase Reference | 506-59-2(CAS DataBase Reference) | | EPA Substance Registry System | Methanamine, N-methyl-, hydrochloride (506-59-2) |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-36/37-37/39-36 | | WGK Germany | 1 | | RTECS | IQ0220000 | | F | 3-9 | | TSCA | Yes | | HS Code | 29211190 | | Toxicity | LD50 in mice (g/kg): 1.21 i.v., 2.00 s.c. (Hazard); LC50 in mice (ppm): 7650 (48 hr), 4725 (14 day); in rats (ppm): 4540 (6 hr) (Steinhagen) |
| Dimethylamine hydrochloride Usage And Synthesis |
| Chemical Properties | white crystals | | Uses | Dimethylamine hydrochloride is a precursor to several industrially significant compounds. | | Uses | As accelerator in vulcanizing rubber, tanning, manufacture of detergent soaps, or attracting boll weevils to exterminate them. As reagent for Mg. | | Uses | Dimethylamine hydrochloride is used as an intermediate in the manufacture of pharmaceuticals like ranitidine and metformin, tramadol and amlodipine. It is used as a precursor of atrazine. It is associated with sodium acetate and used to carry out the Willgerodt- Kindler reaction to prepare amides. Its free base reacts with carbon disulfide to get dimethyldithiocarbamate which is used in rubber vulcanization. It is involved in the synthesis of dimethyl-(1-methyl-pyrrol-2-ylmethyl)-amine by reacting with 1-methyl pyrrole and formaldehyde. | | Application | Dimethylamine hydrochloride is a raw material for organic synthesis. It is also used as a catalyst and magnesium reagent for acetylation analysis.Dimethylamine hydrochloride has been used in the preparation of hexamethylmelamine-methyl-14C. It has also been used to prepare the standard solution of methylamine (MA), dimethylamine (DMA), trimethylamine (TMA), and trimethylamine-N-oxide (TMAO) while determing methylamines and trimethylamine-N-oxide in particulate matter. Dimethylamine hydrochloride is used as an intermediate in the manufacture of pharmaceuticals like ranitidine and metformin, amlodipine. It is used as a precursor of atrazine. It is associated with sodium acetate and used to carry out the Willgerodt- Kindler reaction to prepare amides. Its free base reacts with carbon disulfide to get dimethyldithiocarbamate which is used in rubber vulcanization. It is involved in the synthesis of dimethyl-(1-methyl-pyrrol-2-ylmethyl)-amine by reacting with 1-methyl pyrrole and formaldehyde.
| | Preparation | Dimethylamine hydrochloride is obtained from the salt formation of dimethylamine and hydrochloric acid. | | Flammability and Explosibility | Nonflammable | | Purification Methods | Crystallise the salt from hot CHCl3 or absolute EtOH. It also recrystallises from MeOH/ether solution. Dry it in a vacuum desiccator over H2SO4, then P2O5. Hygroscopic. [Beilstein 4 IV 132.] |
| Dimethylamine hydrochloride Preparation Products And Raw materials |
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