| PAC1 Basic information |
| Product Name: | PAC1 |
| Synonyms: | PAC1;4-(Phenylmethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide;PAC1,4-(PhenylMethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]Methylene]hydrazide;4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide;PAC-1,PAC1;Procaspase activating coMpound 1;(E)-N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide;4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide PAC-1 |
| CAS: | 315183-21-2 |
| MF: | C23H28N4O2 |
| MW: | 392.49 |
| EINECS: | |
| Product Categories: | Inhibitor;Inhibitors |
| Mol File: | 315183-21-2.mol |
| PAC1 Chemical Properties |
| density | 1.14 |
| storage temp. | Store at +4°C |
| solubility | DMSO: ≥10mg/mL |
| form | solid |
| pka | 8.82±0.40(Predicted) |
| color | white |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol must be stored under inert gas at -80°C and will be stable for up to 2 months. |
| Safety Information |
| Hazard Codes | Xn,N |
| Risk Statements | 22-36/37/38-50/53 |
| Safety Statements | 26-36/37-60-61 |
| RIDADR | UN 3077 |
| WGK Germany | 3 |
| HS Code | 29335990 |
| MSDS Information |
| PAC1 Usage And Synthesis |
| Description | PAC-1 (315183-21-2) is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3, EC50=0.22 μM.1 It is less potent at activating procaspase-7, EC50=4.5 μM. It induces apoptosis in a variety of cancer cell lines. The mechanism of activation involves sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate.2?? Sensitizes cancer cells to various chemotherapeutic agents.3 |
| Uses | PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM. |
| Biological Activity | Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC 50 = 0.22 μ M). Also activates procaspase-7 in a less efficient manner (EC 50 = 4.5 μ M). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC 50 values are 0.003-1.41 and 5.02-9.98 μ M respectively). |
| References | 1) Putt et al. (2006), Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy; Nat. Chem. Biol., 2 543 2) Peterson et al. (2009), PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition; J. Mol. Biol., 388 144 3) Bolham et al. (2016), Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with diverse Chemotherapeutics; ACS Cent. Sci., 2 545 |
| PAC1 Preparation Products And Raw materials |
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