Trimethyl orthobutyrate

CAS No.：43083-12-1

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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Trimethyl orthobutyrate Basic information

Product Name:	Trimethyl orthobutyrate
Synonyms:	Butane, 1,1,1-trimethoxy-;ORTHO-N-BUTYRIC ACID TRIMETHYL ESTER;ORTHOBUTYRIC ACID TRIMETHYL ESTER;TRIMETHYL ORTHOBUTYRATE;1,1,1-TRIMETHOXYBUTANE;Trimethyl orthobutylate;RimethylOrthobutyrate;o-Trimethyl butyrate
CAS:	43083-12-1
MF:	C7H16O3
MW:	148.2
EINECS:	256-079-9
Product Categories:	Organic synthesis;Intermediates of Dyes and Pigments;Orthoesters
Mol File:	43083-12-1.mol

Trimethyl orthobutyrate Chemical Properties

Boiling point	145-147 °C (lit.)
density	0.926 g/mL at 25 °C (lit.)
refractive index	1.402-1.404
Fp	50 °C
storage temp.	Flammables area
solubility	Chloroform, Ethyl Acetate
form	Liquid
color	Clear colorless to slightly yellow
Specific Gravity	0.926
BRN	1737319
CAS DataBase Reference	43083-12-1(CAS DataBase Reference)
NIST Chemistry Reference	Trimethyl orthobutyrate(43083-12-1)

Safety Information

Hazard Codes	Xi,F
Risk Statements	36/38-10-36/37/38
Safety Statements	37/39-26-16-36
RIDADR	UN 3272
WGK Germany	3
HazardClass	3.2
PackingGroup	III
HS Code	29159000

MSDS Information

Provider	Language
ACROS	English

Trimethyl orthobutyrate Usage And Synthesis

Chemical Properties	Clear colorless to slightly yellow liquid
Uses	Trimethyl orthobutyrate has been used in the preparation of: 5-acetamido-9-O-butyroyl-3,5-dideoxy-D-glycero-2-nonulo pyranosonic acid 9-O-butyroyl-3,5-dideoxy-5-glycoloylamido-D-glycero-2-nonulo pyranosonic acid
Uses	Trimethyl orthobutyrate can be used for: Acylation at OH-9 of N-acetylneuraminic acid and N-glycoloylneuraminic acid to give the corresponding 9-O-acylated derivatives. Conversion of 2-amino-N-(1-H-benzimidazol-2-yl)benzamide to 2-propyl-3-benzimidazolyl-4(3H)-quinazolinone. Preparation of 2-propyl substituted benzimidazoles from 1,2-benzenediamines. It can also be used in the total synthesis of dl-camptothecin, Olmesartan Medoxomil, DE and CDE ring analogs of camptothecin, and homologs of 1,25-dihydroxyvitamin D₃.
General Description	Kinetics and mechanism of gas-phase elimination of trimethyl orthobutyrate has been examined over the temperature range of 310-369°C and pressure range of 50-130Torr.

Trimethyl orthobutyrate Preparation Products And Raw materials

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