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| UDP-ALPHA-D-N-ACETYLGLUCOSAMINE, DISODIUM SALT Basic information |
| UDP-ALPHA-D-N-ACETYLGLUCOSAMINE, DISODIUM SALT Chemical Properties |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 22-26-36 | | WGK Germany | 3 | | HS Code | 29349990 |
| UDP-ALPHA-D-N-ACETYLGLUCOSAMINE, DISODIUM SALT Usage And Synthesis |
| Chemical Properties | White to off-white crystalline powder | | Uses | Uridine-5'-diphospho-N-acetylglucosamine sodium salt is used as a chemical reagent in studies relating to the synthesis of immunogens.
| | Uses | GlcNAc transferase substrate | | Uses | Uridine 5′-diphospho-N-acetylglucosamine (UDP-GlcNAc) sodium salt has been used:- as a component of reaction cocktail in endoplasmic reticulum to Golgi transport assay
- as a reference standard for the quantification of UDP-GlcNAc in liver tissues using high-performance liquid chromatography (HPLC)
- in testing the glycosylation activity of O-GlcNAc transferase (OGT) against peptide substrate
| | General Description | Uridine 5′-diphospho-N-acetylglucosamine (UDP-GlcNAc) is a nucleotide sugar. It is synthesized from glucose via the hexosamine biosynthetic pathway (HBP). UDP-GlcNAc is transported actively into Golgi, nucleotide sugar transporter (NST). The levels of UDP-GlcNAc is modulated by the concentration of nutrients exposed to the cell. | | Biochem/physiol Actions | Uridine 5′-diphospho-N-acetylglucosamine (UDP-GlcNAc) is a sugar donor and aids in the endomembrane glycosylation of endoplasmic reticulum and Golgi. The decreased levels of UDP-GlcNAc has an influence on the normal cellular proliferation and apoptosis. UDP-GlcNAc elicits feedback inhibition of the enzyme glutamine:fructose-6-phosphate amidotransferase (GFAT). |
| UDP-ALPHA-D-N-ACETYLGLUCOSAMINE, DISODIUM SALT Preparation Products And Raw materials |
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