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| 4-Benzylpiperidine Basic information |
| 4-Benzylpiperidine Chemical Properties |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | TM4728000 | | TSCA | Yes | | HazardClass | IRRITANT | | HS Code | 29333990 |
| 4-Benzylpiperidine Usage And Synthesis |
| Chemical Properties | clear colourless to yellow viscous liquid. | | Uses | 4-Benzylpiperidine was studied as acid corrosion inhibitor for iron. It was also used to study potential utility of dopamine-welective releaser as a treatment for cocaine dependence. In an assay of cocaine discrimination, 4-Benzylpiperidine had the most rapid onset and shortest duration of action. | | Preparation | 4-Benzylpiperidine can be prepared by reacting 4-cyanopyridine with toluene. Catalytic hydrogenation of the pyridine ring then completes the synthesis. | | Application | Reactant for synthesis of:AntiproliferativesGABA uptake inhibitorsPyridinesHistamine H3 antagonistsMultipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer′s and neuronal vascular diseasesAntiserotoninergic, antiplatelet, hemorheologic, antiarrythmic and antioxidant molecules via nucleophilic substitution | | Synthesis Reference(s) | Synthesis, p. 741, 1980 DOI: 10.1055/s-1980-29196 | | General Description | 4-Benzylpiperidine is dopamine-selective releaser. It is a potential candidate for treatments for cocaine dependence. | | Biochem/physiol Actions | 4-Benzylpiperidine inhibits the activity of rat brain monoamine oxidase-A and -B, with IC50 values of 0.02 mM and 2 mM respectively. It acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It is most efficacious as a releaser of norepinephrine, with an ec50 of 109/41.4/5246nM for DA/NE/5HT, respectively . It has a fast onset of action and a short duration. It also functions as a monoamine oxidase inhibitor (MAOI) with preference for MAO-A. |
| 4-Benzylpiperidine Preparation Products And Raw materials |
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