Product

Licochalcone B

CAS No.：58749-23-8

Other grades of this product :

Licochalcone B Basic information

Product Name:	Licochalcone B
Synonyms:	3,4,4'-Trihydroxy-2-Methoxychalcone;LICOCHALCONEB;(E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one;3,4,4'-Trihydroxy-2-methoxy-trans-chalcone;2-Propen-1-one,3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)-;Licoagrochalcone B
CAS:	58749-23-8
MF:	C16H14O5
MW:	286.28
EINECS:
Product Categories:	chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File:	58749-23-8.mol

Licochalcone B Chemical Properties

Melting point	196-197℃
Boiling point	550.5±50.0 °C(Predicted)
density	1.369±0.06 g/cm3 (20 ºC 760 Torr)
pka	7.80±0.15(Predicted)

Safety Information

MSDS Information

Licochalcone B Usage And Synthesis

Chemical Properties	Licochalcone B is a yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents,and it is derived from licorice rhizomes.
Uses	Licochalcone B has anti-tumor, anti-inflammatory, and antioxidant effects.It can be used for content determination, identification, pharmacological experiments, etc.
Biological Activity	Licochalcone B is extracted from Glycyrrhizainflate root. LICOCHALCONEB inhibits the self-aggregation of amyloid β (Aβ420) (IC50=2.16 μM) and disintegrates pre-formed Aβ42 fibrils, reducing metal-induced Aβ42 aggregation by chelating metal ions.

Licochalcone B Preparation Products And Raw materials

Raw materials

1-[4-(methoxymethoxy)phenyl]ethan-1-one-->1-[4-(Tetrahydro-pyran-2-yloxy)-phenyl]-ethanone-->4'-Hydroxyacetophenone-->2,3,4-Trihydroxybenzaldehyde

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