4-Fluoroanisole

CAS No.：459-60-9

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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4-Fluoroanisole Basic information

Synthesis

Product Name:	4-Fluoroanisole
Synonyms:	P-FLUOROANISOLE;4-FLUOROANISOL;4-FLUOROANISOLE;4-METHOXYFLUOROBENZENE;1-FLUORO-4-METHOXYBENZENE;1-fluoro-4-methoxy-benzen;Anisole, p-fluoro-;Benzene,1-fluoro-4-methoxy
CAS:	459-60-9
MF:	C7H7FO
MW:	126.13
EINECS:	207-295-7
Product Categories:	Aromatics, Metabolites & Impurities;Aromatics;Fluorinated benzene series;Metabolites & Impurities;Aryl Fluorinated Building Blocks;Building Blocks;C2 to C7;C7-C8;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Oxygen Compounds;Benzene series;AnisoleSeries;Fluorobenzene;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Ethers;Organic Building Blocks;Oxygen Compounds;bc0001
Mol File:	459-60-9.mol

4-Fluoroanisole Chemical Properties

Melting point	−45 °C(lit.)
Boiling point	157 °C(lit.)
density	1.114 g/mL at 25 °C(lit.)
refractive index	n20/D 1.488(lit.)
Fp	110 °F
storage temp.	Sealed in dry,Room Temperature
form	Liquid
Specific Gravity	1.114
color	Clear colorless to light yellow
Water Solubility	Not miscible or difficult to mix in water.
BRN	1281425
InChIKey	VIPWUFMFHBIKQI-UHFFFAOYSA-N
CAS DataBase Reference	459-60-9(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1-fluoro-4-methoxy-(459-60-9)
EPA Substance Registry System	p-Fluoroanisole (459-60-9)

Safety Information

Hazard Codes	F
Risk Statements	10
Safety Statements	16
RIDADR	UN 3271 3/PG 3
WGK Germany	3
Hazard Note	Flammable
TSCA	T
HazardClass	3
PackingGroup	III
HS Code	29093090

MSDS Information

Provider	Language
1-Fluoro-4-methoxybenzene	English
ACROS	English
SigmaAldrich	English
ALFA	English

4-Fluoroanisole Usage And Synthesis

Synthesis	Fluorine itself reacts with a 4-substituted methoxy benzene tin derivative to give 4-fluoroanisole.
Chemical Properties	Colorless to light yellow liquid
Uses	An Acetanilide and Anisole derivative metabolite by liver.
Uses	4-Fluoroanisole is a raw material for medicine and intermediate.
Synthesis Reference(s)	The Journal of Organic Chemistry, 51, p. 1886, 1986 DOI: 10.1021/jo00360a042

4-Fluoroanisole Preparation Products And Raw materials

Raw materials	3-Fluorobenzotrifluoride
Preparation Products	2-FLUORO-5-HYDROXYBENZOIC ACID-->2-FLUORO-5-METHOXYBENZOIC ACID-->5-Fluoro-2-methoxyphenylboronic acid-->2-Bromo-4-fluoroanisole-->2-Chloro-4-fluorophenol-->Umbralisib-->4-Fluorophenyl acetate-->2-FLUORO-5-METHOXYBENZONITRILE-->5-METHOXY-1H-INDAZOLE

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