PHTHALAMIC ACID

CAS No.：88-97-1

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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PHTHALAMIC ACID Basic information

Product Name:	PHTHALAMIC ACID
Synonyms:	2-(Aminocarbonyl)benzoic acid;Phthalamic acid ,99%;2-Carbamoylbenzoic acid;o-Carbamoylbenzoic acid;Phthalamide acid;Phthalic acid monoamide;Phthalic monoamide;Phthalamic acid 97%
CAS:	88-97-1
MF:	C8H7NO3
MW:	165.15
EINECS:	201-871-1
Product Categories:	C8;Carbonyl Compounds;Carboxylic Acids;Building Blocks;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks
Mol File:	88-97-1.mol

PHTHALAMIC ACID Chemical Properties

Melting point	140-143 °C(lit.)
Boiling point	394.2±25.0 °C(Predicted)
density	1.368
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	3.75±0.10(Predicted)
color	White to Off-White
BRN	1868205
CAS DataBase Reference	88-97-1(CAS DataBase Reference)
EPA Substance Registry System	Benzoic acid, 2-(aminocarbonyl)- (88-97-1)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
TSCA	Yes
HazardClass	IRRITANT
HS Code	2924297099

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

PHTHALAMIC ACID Usage And Synthesis

Uses	Phthalamic Acid is a reactant in the synthesis of phthalimide derivatives with analgesic activity.
Uses	Phthalamic acid may be used to synthesize anthranilic acid via reaction with sodium hypochlorite.
General Description	Phthalamic acid can be synthesized from the reaction between ammonia and phthalic anhydride by a modified Auger′s method. Kinetic studies of the intramolecular carboxylic-group assisted hydrolysis of amide bond of phthalamic acid provided the value of pseudo-first order rate constant (k_obs) as 5.1×10^-5sec^-1 at pH 1.3-1.8 and 35^°C. It undergoes hydrolysis about 105 times faster than benzamide.

PHTHALAMIC ACID Preparation Products And Raw materials

Raw materials	Hydrochloric acid-->Potassium hydroxide-->Phthalimide-->Silver nitrate
Preparation Products	Bentazone

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