1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

CAS No.：79183-19-0

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1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Basic information

Product Name:	1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
Synonyms:	APOPTOSIS ACTIVATOR 2;APOPTOSIS ACTIVATOR II;1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE;1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE;1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]-;Apoptosis Activator 2, >=98%;Apoptosis Activator 2, 97%, a cytochrome c caspase activator and apoptosis inducer;CS-572
CAS:	79183-19-0
MF:	C15H9Cl2NO2
MW:	306.14
EINECS:	200-256-5
Product Categories:	Inhibitors;Caspases/Apoptosis
Mol File:	79183-19-0.mol

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Chemical Properties

Boiling point	470.6±55.0 °C(Predicted)
density	1.494
Fp	238.4℃
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	Soluble in DMSO
pka	-2.69±0.20(Predicted)
form	Orange to red solid.
Sensitive	Light Sensitive

Safety Information

Safety Statements	24/25
RIDADR	3077
HS Code	29145090

MSDS Information

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Usage And Synthesis

Uses	Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.
Uses	Activates apoptosis in cells; shows selectivity for cancer cells against normal cell lines
Biological Activity	Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC 50 = 4-9 μ M for leukaemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC 50 > 40 μ M).
references	[1] nguyen jt, wells ja. direct activation of the apoptosis machinery as a mechanism to target cancer cells. proc natl acad sci u s a. 2003 jun 24;100(13):7533-8.[2] nguyen tv, jayaraman a, quaglino a, pike cj. androgens selectively protect against apoptosis in hippocampal neurones. j neuroendocrinol. 2010 sep;22(9):1013-22.

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Preparation Products And Raw materials

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