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| Isoliquiritigenin Basic information |
| Product Name: | Isoliquiritigenin | | Synonyms: | gu17;Isqliquiritigenin;ISOLIQUIRTEGENIN (2',4,4'-TRIHYDROXYCHAL;ISOLIQUIRITIGENIN(P);ISOLIQUIRITIGENIN(RG);(E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, 4,2μ,4μ-Trihydroxychalcone;Isoliquiritigenin，4,2',4'-Trihydroxychalcone;(E)-2',4,4'-Trihydroxychalcone | | CAS: | 961-29-5 | | MF: | C15H12O4 | | MW: | 256.25 | | EINECS: | 607-884-2 | | Product Categories: | The group of Liquorice;sy;Chalcones;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors | | Mol File: | 961-29-5.mol |
| Isoliquiritigenin Chemical Properties |
| Melting point | 206-210°C | | Boiling point | 504.0±42.0 °C(Predicted) | | density | 1.384±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | H2O: <0.1 mg/mL | | pka | 7.50±0.35(Predicted) | | form | powder | | color | yellow to orange | | Sensitive | Light Sensitive & Hygroscopic | | BRN | 1914296 | | InChIKey | DXDRHHKMWQZJHT-FPYGCLRLSA-N | | CAS DataBase Reference | 961-29-5(CAS DataBase Reference) |
| Risk Statements | 36/37/38 | | Safety Statements | 26-37 | | WGK Germany | 3 | | RTECS | FL7080000 | | HS Code | 29145090 |
| Isoliquiritigenin Usage And Synthesis |
| Chemical Properties | Yellow solid | | Uses | aldose reductase inhibitor, antineoplastic, antiinflammatory | | Uses | Isoliquiritigenin (ISL) is a flavonoid found in licorice root and several other plants that displays antioxidant, anti-inflammatory, and antitumor activities as well as hepatoprotection against steatosis-induced oxidative stress. ISL induces quinone reductase-1, a phase II enzyme that deactivates radicals and electrophiles, with a concentration required to double activity (CD) value of 1.8 μM in murine hepatoma cells. | | Uses | Isoliquiritigenin (ISL) is a flavonoid found in licorice root and several other plants that displays antioxidant, anti-inflammatory, and antitumor activities as well as hepatoprotection against steatosis-induced oxidative stress. ISL induces quinone reduc | | General Description | Isoliquiritigenin is an aromatic ketone and belongs to the chalcone group of compound. It is derived from licorice and is a component in medicine and food. | | Biochem/physiol Actions | Isoliquiritigenin is a soluble guanylyl cyclase activator and possesses antitumor activity. It also possesses antioxidant, antiplatelet and estrogenic properties. | | Anticancer Research | It is extracted from Dipteryx odorata seeds, found to be active in induction of quininereductase, and thus prevents chemical carcinogenesis. In a dose- and time-dependentmanner, it significantly inhibits the proliferation of prostate cancer cells,and this isoliquiritigenin-induced cell cycle arrest and antiproliferative effects maybe manifested by growth arrest- and DNA damage-inducible gene 153 (GADD153).It induces apoptosis in prostate cancer cells through mitochondrial apoptosispathway in which mitochondrial membrane potential is disrupted, cytochrome-cand Smac/Diablo are released, and caspase-9 is activated. It is reported to enhancethe expression of universal inhibitor of cyclin-dependent kinases, p21CIP1/WAF1, in adose- and time-dependent manner in A549 human lung cancer cells (Kanazawaet al. 2003; Ii et al. 2004; Balunas and Kinghorn 2005; Jung et al. 2006). |
| Isoliquiritigenin Preparation Products And Raw materials |
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