Other grades of this product :
| PHACLOFEN Basic information |
| Product Name: | PHACLOFEN | | Synonyms: | 3-AMINO-2-(4-CHLOROPHENYL)PROPYLPHOSPHONIC ACID;PHACLOFEN;(RS)-3-AMINO-2-(4-CHLOROPHENYL)PROPYLPHOSPHONIC ACID;3-amino-2-(4-chlorophenyl)*propanephosphonic acid;PHACLOFEN GABA(B) RECEPTOR ANTA;Phosphonic acid, (3-amino-2-(4-chlorophenyl)propyl)-;Phosphonic acid, P-[3-amino-2-(4-chlorophenyl)propyl]-;Phaclofen,(RS)-3-Amino-2-(4-chlorophenyl)propylphosphonicaci | | CAS: | 114012-12-3 | | MF: | C9H13ClNO3P | | MW: | 249.63 | | EINECS: | | Product Categories: | GABA/Glycine receptor | | Mol File: | 114012-12-3.mol |
| PHACLOFEN Chemical Properties |
| storage temp. | Store at RT | | solubility | 0.1 M HCl: 13.3 mg/mL | | form | solid | | color | white |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| PHACLOFEN Usage And Synthesis |
| Uses | Phaclofen is a selective GABAB?receptor antagonist. | | General Description | Phaclofen is a phosphonic acid derivative of baclofen. | | Biological Activity | Selective GABA B antagonist. Phosphono analog of GABA B agonist baclofen ((RS)-4-Amino-3-(4-chlorophenyl)butanoic acid ). | | Biochem/physiol Actions | Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and (?) baclofen interact. Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K+ dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons. |
| PHACLOFEN Preparation Products And Raw materials |
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