Product

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E

CAS No.：141286-78-4

Other grades of this product :

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Basic information

Product Name:	2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E
Synonyms:	2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide;2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide (PEPA)
CAS:	141286-78-4
MF:	C16H16F2N2O4S2
MW:	402.44
EINECS:
Product Categories:
Mol File:	141286-78-4.mol

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Chemical Properties

storage temp.	protect from light
solubility	DMSO: >20mg/mL
form	solid
color	white
InChIKey	GTACSIONMHMRPD-UHFFFAOYSA-N

Safety Information

WGK Germany

MSDS Information

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Usage And Synthesis

Uses	PEPA is an allosteric potentiator of AMPA desensitization.
Biological Activity	Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluR3/4 > GluR1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration.
Biochem/physiol Actions	2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist that reduces ischemia-induced performance deficits in rats.

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Preparation Products And Raw materials

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