N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride

CAS No.：1715-30-6

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N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride Basic information

Product Name:	N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride
Synonyms:	Bisguanidine;N,N''-Bis(2-ethylhexyl)-3,12-diiMino-2,4,11,13-tetraazatetradecanediiMidaMide;Sterwin 904;1,1'-Hexamethylenebis[5-(2-ethylhex-1-yl)]biguanide dihydrochloride;Alexidine dihydrochloride, N,N''''-Hexane-1,6-diylbis[N'-(2-ethylhex-1-yl)(imidodicarbonimidic diamide)] dihydrochloride;N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride;Bisguadine;Compound-904
CAS:	1715-30-6
MF:	C26H58Cl2N10
MW:	581.71172
EINECS:	216-994-6
Product Categories:	Aliphatics;Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labelled Compounds
Mol File:	1715-30-6.mol

N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride Chemical Properties

Melting point	220.6-223.4°C
storage temp.	-20°C
solubility	DMSO: ≥10mg/mL
form	powder
color	white to off-white
EPA Substance Registry System	2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(2-ethylhexyl)-3,12-diimino-, dihydrochloride (1715-30-6)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
WGK Germany	3
HS Code	2925290090

MSDS Information

N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride Usage And Synthesis

Chemical Properties	White Powder with Light Yellow Cast
Uses	Has antibacterial, antiplaque properties against Streptococcus mutans, Actinomyces ciscosus, and Actinomyces naesludii.
Uses	Alexidine dihydrochloride has been used: as an antiseptic to study its antimicrobial activity in saliva-derived microcosm biofilms as a protein tyrosine phosphatase localized to the mitochondrion 1 (PTPMT1)-specific inhibitor to study its effects on spare respiratory capacity and viability of CD8⁺ T cells as a PTPMT1 inhibitor to study its antiviral effect on ?human cytomegalovirus?(HCMV) replication in HCMV-infected human foreskin fibroblast (HFF) cells
Biological Activity	selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (ptpmt1) (ic50 = 1.08 μm in vitro). stimulates increased insulin secretion by β-cells in rat pancreatic islets. displays antitcancer properties in fadu cells.
Biochem/physiol Actions	Alexidine dihydrochloride is a bisbiguanide compound. It has been studied in the treatment of head and neck cancer. Alexidine dihydrochloride also exhibits antibiofilm and antifungal activity against several fungal species. It causes mitochondrial apoptosis in mammalian cells due to its anti-cancer activity. Alexidine dihydrochloride is a component of oral disinfectant and contact lens solution.

N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride Preparation Products And Raw materials

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