Product

4-Nitrobenzenesulfonyl chloride

CAS No.：98-74-8

Other grades of this product :

4-Nitrobenzenesulfonyl chloride Basic information

Product Name:	4-Nitrobenzenesulfonyl chloride
Synonyms:	4-nitro-benzenesulfonylchlorid;4-Nitrophenylsulfonyl chloride;p-Nitrobenzenesulfonic acid chloride;4-Nitrobenzenesulfonyl chloride,95%;4-Nitrobenzenesulfonyl chloride, 95% 25GR;The nitrobenzene sulfonyl chloride;5-Nitrobenzenesulfonyl chloride;4-Nitrobenzenesulfonyl chloride ,99%
CAS:	98-74-8
MF:	C6H4ClNO4S
MW:	221.62
EINECS:	202-697-9
Product Categories:	Dyestuff Intermediates;Phenyls & Phenyl-Het;Sulphonyl Chlorides;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;Benzene derivatives;Benzene series;Phenyls & Phenyl-Het;Sulphonyl Chlorides
Mol File:	98-74-8.mol

4-Nitrobenzenesulfonyl chloride Chemical Properties

Melting point	75 °C
Boiling point	143-144 °C (1.5002 mmHg)
density	1.602 (estimate)
vapor pressure	0.009Pa at 20℃
refractive index	1.6000 (estimate)
Fp	143-144°C/1.5mm
storage temp.	Store below +30°C.
solubility	soluble in Toluene
form	Powder
color	yellow
PH	1 (H2O, 20℃)
Water Solubility	Insoluble
Sensitive	Moisture Sensitive
BRN	746543
LogP	2.1 at 20℃
CAS DataBase Reference	98-74-8(CAS DataBase Reference)
NIST Chemistry Reference	4-Nitrobenzenesulphonyl chloride(98-74-8)
EPA Substance Registry System	Benzenesulfonyl chloride, 4-nitro- (98-74-8)

Safety Information

Hazard Codes	C
Risk Statements	34-52/53
Safety Statements	26-36/37/39-45-61
RIDADR	UN 3261 8/PG 2
WGK Germany	3
F	21
Hazard Note	Corrosive/Moisture Sensitive
TSCA	Yes
HazardClass	8
PackingGroup	II
HS Code	29049085

MSDS Information

Provider	Language
4-Nitrobenzene-1-sulfonyl chloride	English
SigmaAldrich	English
ACROS	English
ALFA	English

4-Nitrobenzenesulfonyl chloride Usage And Synthesis

Chemical Properties	yellow to brown powder
Uses	4-Nitrobenzenesulfonyl Chloride is used in the preparation of N-Nosyl-α-amino acid for peptide synthesis.
Uses	4-Nitrobenzenesulfonyl chloride is used as an intermediate for the synthesis of pharmaceuticals like foscmprenavir, darunavir and amprenavir. It is involved in the preparation of N-nosyl-alpha-amino acid for peptide synthesis. It is also used for stereoselective α-glucosylation of partially protected carbohydrates in association with silver tri-fluoromethanesulfonate, N,N-dimethylacetamide and triethylamine. It is widely used for the synthesis of hydroxylamines of sulfadiazine, sulfamethoxazole and [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2'-bipyridine, nbs = 4-nitrobenzenesulfonate).
Uses	4-Nitrobenzenesulfonyl chloride was used in the synthesis of [Cu(bipy)₂Cl](nbs) (1) (bipy = 2,2′-bipyridine, nbs = 4-nitrobenzenesulfonate) hydroxylamines of sulfadiazine and sulfamethoxazole solution phase peptide using N-nosyl-α-amino acids.
Flammability and Explosibility	Notclassified

4-Nitrobenzenesulfonyl chloride Preparation Products And Raw materials

Raw materials	Nitric acid-->DIPHENYL DISULFIDE
Preparation Products	Benazepril-->1-(4-NITROBENZENESULFONYL)-1H-1,2,4-TRIAZOLE-->4-Nitrobenzenesulfonamide-->Sulfisoxazole-->Sulfapyridine-->Sulfamonomethoxine-->4-Nitrophenylboronic acid pinacol ester-->METHYL 4-NITROBENZENESULFONATE-->4-AMINO-N-ETHYL-BENZENESULFONAMIDE-->DE-6-->R-2-METHYL GLYCIDYL P-NOSYLATE-->sulfapyrazole-->4-(MORPHOLINE-4-SULFONYL)-PHENYLAMINE

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