2-Methyl-4-isothiazolin-3-one hydrochloride

CAS No.：26172-54-3

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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2-Methyl-4-isothiazolin-3-one hydrochloride Basic information

Product Name:	2-Methyl-4-isothiazolin-3-one hydrochloride
Synonyms:	3(2H)-Isothiazolone,2-methyl-,hydrochloride;MIT HYDROCHLORIDE;2-Methylisothiazol-3-one hydrochloride;2-METHYL-4-ISOTHIAZOLIN-3-ONE HYDROCHLORIDE;2-methyl-2H-isothiazol-3-one hydrochloride;2-METHYL-4-ISOTHIAZOLIN-3-ONE HCL;N-MethylisothiazoloneHCl;ISO-THIAZOLINONE(KATHON)
CAS:	26172-54-3
MF:	C4H6ClNOS
MW:	151.61
EINECS:	247-499-3
Product Categories:	Amines;Heterocycles;Sulfur & Selenium Compounds
Mol File:	26172-54-3.mol

2-Methyl-4-isothiazolin-3-one hydrochloride Chemical Properties

density	1.551 at 21℃
vapor pressure	0.777-1Pa at 20-25℃
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White
BRN	3993054
LogP	-0.44 at 20℃ and pH2
Surface tension	71.3mN/m at 1g/L and 20℃
CAS DataBase Reference	26172-54-3(CAS DataBase Reference)
EPA Substance Registry System	3(2H)-Isothiazolone, 2-methyl-, hydrochloride (26172-54-3)

Safety Information

Hazard Codes	C
Risk Statements	34-42/43
Safety Statements	26-36/37/39-45
RIDADR	UN 1759 8/PG 2
WGK Germany	3
HS Code	2934100090

MSDS Information

Provider	Language
SigmaAldrich	English

2-Methyl-4-isothiazolin-3-one hydrochloride Usage And Synthesis

Uses	2-Methyl-4-isothiazolin-3-one Hydrochloride is an isothiazolinone based biocide and preservative used in personal care products. It is also implicated as an allergen. It is also used for controlling microbial growth in water-containing solution.
Application	Methylisothiazolinone (MIT) has been used: as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell deathto study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites
General Description	2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a derivative of the synthetic isothiazolinone.
Biochem/physiol Actions	2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a skin sensitizer known to cause contact dermatitis and allergy. It is extensively used in the cosmetic industry as a preservative. MIT is a neurotoxin and its prolonged exposure may lead to neuronal death and inhibition of neurite outgrowth.

2-Methyl-4-isothiazolin-3-one hydrochloride Preparation Products And Raw materials

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