2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one

CAS No.：27277-00-5

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2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Basic information

Product Name:	2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one
Synonyms:	2-AMINO-6-METHYL-4-PROPYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-5(4H)-ONE;2-AMINO-6-METHYL-4-PROPYL-4H-[1,2,4] TRIAZOLE-[1,5-A] PYRIMIDINE-5-ONE;2-AMINO-6-METHYL-4-PROPYL-4H-[1,2,4]TRIAZOLO-[1,5-A]PYRIMIDIN-5-ONE;2-AMINO-6-METHYL-5-OXO-4-N-PROPYL-4,5-DIHYDRO-S-TRIAZOLE[1,5-A]PYRIMIDINE;ICI 63197;2,4]triazolo[1,5-a]pyrimidin-5(4h)-one,2-amino-6-methyl-4-propyl-[;2-Amio-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one;2-AMINO-6-METHYL-5-OXO-4-N-PROPYL-4,5-DIHYDRO-S-TRIAZOLE[1,5-α]PYRIMIDIN
CAS:	27277-00-5
MF:	C9H13N5O
MW:	207.23
EINECS:	248-383-5
Product Categories:	Cyclic Nucleotide related
Mol File:	27277-00-5.mol

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Chemical Properties

Melting point	161.8-163 °C
Boiling point	459.9±28.0 °C(Predicted)
density	1.44±0.1 g/cm3(Predicted)
vapor pressure	0.004Pa at 25℃
storage temp.	2-8°C
solubility	DMSO: 13 mg/mL
form	solid
pka	2.96±0.40(Predicted)
color	white
Water Solubility	5.7g/L at 20℃
InChIKey	UQDVRVNMIJAGRK-UHFFFAOYSA-N
LogP	0.49 at 20℃
CAS DataBase Reference	27277-00-5(CAS DataBase Reference)
EPA Substance Registry System	2-Amino-4,5-dihydro-6-methyl-4-propyl-s-triazolo-(1,5-a)-pyrimidin-5-one (27277-00-5)

Safety Information

RIDADR	2811
WGK Germany	1
HazardClass	6.1(b)
PackingGroup	III

MSDS Information

Provider	Language
SigmaAldrich	English

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Usage And Synthesis

Uses	ICI 63197 is a specific cAMP phosphodiesterase (PDE) inhibitor. It is potent in anatagonizing reserpine-induced hypothermia. potent PDE4 inhibitor.
Flammability and Explosibility	Notclassified
Biological Activity	Potent phosphodiesterase (PDE) 4 inhibitor (IC 50 = 35 nM for inhibition of [ 3 H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo .
Biochem/physiol Actions	Phosphodiesterase IV (PDE 4) inhibitor

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Preparation Products And Raw materials

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