CHLORISONDAMINE DIIODIDE

CAS No.：96750-66-2

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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CHLORISONDAMINE DIIODIDE Basic information

Product Name:	CHLORISONDAMINE DIIODIDE
Synonyms:	4,5,6,7-tetrachloro-2-methyl-2-[2-(trimethylammonium)ethyl]isoindolinium diiodide;Chlorisondamine (iodide)
CAS:	96750-66-2
MF:	C14Cl4H20I2N2
MW:	611.94
EINECS:
Product Categories:
Mol File:	96750-66-2.mol

CHLORISONDAMINE DIIODIDE Chemical Properties

storage temp.	2-8°C
solubility	H₂O: ~3.75 mg/mL
form	solid
color	white

Safety Information

Hazard Codes	Xn,N
Risk Statements	22-50
Safety Statements	60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	2

MSDS Information

CHLORISONDAMINE DIIODIDE Usage And Synthesis

Description	Chlorisondamine is an antagonist of nicotinic acetylcholine receptors (nAChRs; IC₅₀ = 1.8 μM in rat striatal synaptosomes) and a ganglion blocker. It decreases dopamine release induced by nicotine (Item Nos. 16535 \| 20887) in a dose-dependent manner in rat striatal synaptosomes at concentrations ranging from 0-100 μM. The effect of chlorisondamine is long-lasting, with a 10 mg/kg dose blocking nicotine-induced stimulant activity for at least five weeks. Chlorisondamine (5 μg, i.c.v.) prevents rats from acquiring a (–)-nicotine-induced conditioned taste aversion response, a model of the aversive effects of nicotine. It also inhibits autonomic ganglia, providing approximately 50% inhibition of the contractile response in feline superior cervical ganglion nictitating membrane preparations when administered at a dose of 50 mg/kg.
Uses	Chlorisondamine diiodide has been used: as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress
Biochem/physiol Actions	Chlorisondamine diiodide mediates ganglionic and central blockade.

CHLORISONDAMINE DIIODIDE Preparation Products And Raw materials

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