• CAS No.:98-10-2
Other grades of this product :
Benzenesulfonamide Basic information
Product Name:Benzenesulfonamide
Synonyms:BenzenesulfonaMide, 98+% 500GR;CL160;Benzenesulfonamide Vetec(TM) reagent grade, 98%;Benzenesulfomide;BENZENESULFONYLAMIDE;BENZENESULPHONAMIDE;BENZENESULFONAMIDE;Benzene sulfonamtde
Product Categories:Urinary System Agents;Organic Building Blocks;SULFONAMIDE;Pharmaceutical Intermediates;Sulfonamides/Sulfinamides;Sulfur Compounds;Benzene derivatives;Organics
Mol File:98-10-2.mol
Benzenesulfonamide Chemical Properties
Melting point 149-152 °C (lit.)
Boiling point 315.5±25.0 °C(Predicted)
density 1.274 (estimate)
refractive index 1.5500 (estimate)
Fp 250°C
storage temp. Store below +30°C.
solubility methanol: soluble25mg/mL
pka10.1(at 25℃)
form Powder, Crystals and/or Chunks
color White to off-white
Water Solubility 4.3 g/L (16 ºC)
BRN 1100566
CAS DataBase Reference98-10-2(CAS DataBase Reference)
NIST Chemistry ReferenceBenzenesulfonamide(98-10-2)
EPA Substance Registry SystemBenzenesulfonamide (98-10-2)
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 36
WGK Germany 3
RTECS DA9380000
HS Code 29350090
ToxicityLD50 orally in Rabbit: 991 mg/kg
MSDS Information
Benzenesulfonamide English
SigmaAldrich English
ACROS English
ALFA English
Benzenesulfonamide Usage And Synthesis
Chemical Propertieswhite to off-white granular crystalline powder. insoluble in water, soluble in ethanol and ether. soluble in alkali.
UsesBiospecific adsorption of carbonic anhydrase to self-assembled monolayers of alkanethiolates that present benzenesulfonamide groups on gold. Biospecific binding of carbonic anhydrase to mixed sams presenting benzenesulfonamide ligands led to a model system for studying lateral steric effects. Benzenesulfonamide modifications at c-7 of ciprofloxacin change its primary target instreptococcus pneumoniae from topoisomerase iv to gyrase. Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors.
UsesBenzenesulfonamide was used to develop analytical method for simultaneous determination of benzotriazole, benzothiazole and benzenesulfonamide contaminants in environmental waters.
PreparationBenzenesulfonamide is obtained by amination of benzenesulfonyl chloride.
Synthesis Reference(s)Tetrahedron Letters, 35, p. 7201, 1994 DOI: 10.1016/0040-4039(94)85360-6Synthesis, p. 1031, 1986 DOI: 10.1055/s-1986-31862
Biological Activitybenzenesulfonamide, the amide of benzenesulfonic acid, has been used to produce various derivatives, especially those used as intermediates in the synthesis of photochemicals, dyes, disinfectants, as well as pharmaceuticals.
Biochem/physiol ActionsBenzenesulfonamide is an inhibitor of human carbonic anhydrase B. Benzenesulfonamide derivatives are effective in the treatment of proliferative diseases such as cancer. It is used in the synthesis of dyes, photochemicals and disinfectants.
Safety ProfileModerately toxic by ingestion andintraperitoneal routes. When heated to decomposition itemits very toxic fumes of SOx and NOx.
in vitroin a previous study, a series of n-aryl-β-alanine- and diazo-derivatives of benzenesulfonamide were designed, synthesized, and their binding affinities to carbonic anhydrases (ca) i, ii, vi, vii, xii, and xiii was investigated by the use of isothermal titration calorimetry and fluorescent thermal shift assay. the results indicated that 4-substituted diazobenzenesulfonamides were found to be most potent ca binders among the synthesized derivatives. in addition, the majority of the n-aryl-β-alanine derivatives had better affinity for ca ii while diazobenzenesulfonamides showed nanomolar affinities towards ca i isozyme. moreover, the x-ray crystallographic data showed the binding modes of both derivative groups [1].
in vivoin the rat cpe model, the most potnet benzenesulfonamide indole derivative at 10 mg/kg in the mc/tw formulation displayed oral efficacy. moreover, this compound, when administered in another preferred, minimal formulation in the same in vivo model, demonstrated superior oral efficacy to the lead phenylmethane sulfonamide way-196025 orally administered in a lipid-based formulation. in addition, this benzenesulfonamide indole derivative was also orally efficacious at 1 mg/kg by attenuating both lar and the associated ahr to aerosolized carbachol in naturally sensitized sheep, which had been challenged through the airways with a. suum antigen [2].
references[1] rutkauskas k et al. 4-amino-substituted benzenesulfonamides as inhibitors of human carbonic anhydrases. molecules. 2014 oct 28;19(11):17356-80. [2] lee kl et al. benzenesulfonamide indole inhibitors of cytosolic phospholipase a2α: optimization of in vitro potency and rat pharmacokinetics for oral efficacy. bioorganic and medicinal chemistry. 2008 16(3), 1345-1358.


Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

  • NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
  • +86-23-6139-8061 +86-13650506873
  • WhatsApp +86-13650506873






Google translate: 日本语 한국어 Français Deutsch España Türkiye