DL-Propargylglycine

CAS No.：16900-57-5

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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DL-Propargylglycine Basic information

Product Name:	DL-Propargylglycine
Synonyms:	2-Aminopent-4-ynoic acid hydrochloride;DL-2-Propynylglycine hydrochloride;2-Amino-4-pentynoic acid hydrochloride;2-amino-4-pentynoic Acid Hydrochloride (1:1);DL-Propargylglycine HCl
CAS:	16900-57-5
MF:	C5H7NO2
MW:	113.11458
EINECS:
Product Categories:
Mol File:	16900-57-5.mol

DL-Propargylglycine Chemical Properties

storage temp.

Inert atmosphere,Room Temperature

Safety Information

MSDS Information

DL-Propargylglycine Usage And Synthesis

Description

Hydrogen sulphide (H₂S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-inflammatory mediator. DL-Propargyl glycine (PAG) is an irreversible inhibitor of the H₂S synthesizing enzyme cystathionine-γ-lyase (CSE). PAG blocks H₂S synthesis activity in rat liver preparations with an IC₅₀ value of 55 μM and abolishes the rise in plasma H₂S in anaesthetized rats induced with hemorrhagic shock. At concentrations ranging from 25-100 mg/kg, PAG can reduce H₂S-associated inflammation in rodent models of pancreatitis, oedema, and endotoxemia.

Uses

DL-Propargylglycine Hydrochloride is used in preparation of tert-Butoxycarbonyl Azide.

DL-Propargylglycine Preparation Products And Raw materials

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