Other grades of this product :
| PD158780 Basic information |
| Product Name: | PD158780 | | Synonyms: | N4-(3-Bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine;Pyrido[3,4-d]pyriMidine-4,6-diaMine,N4-(3-broMophenyl)-N6-Methyl- (Related Reference);Pyrido[3,4-d]pyriMidine-4,6-diaMine,N4-(3-broMophenyl)-N6-Methyl-;PD 158780 solution;InSolution? PD 158780;PD 158780 - CAS 171179-06-9 - Calbiochem;InSolution PD 158780 - CAS 171179-06-9 - Calbiochem;PD 158780; PD-158780 | | CAS: | 171179-06-9 | | MF: | C14H12BrN5 | | MW: | 330.18 | | EINECS: | | Product Categories: | | Mol File: | 171179-06-9.mol |
| PD158780 Chemical Properties |
| Melting point | 174.0 to 178.0 °C | | Boiling point | 499.6±45.0 °C(Predicted) | | density | 1.611±0.06 g/cm3 (20 ºC 760 Torr) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | DMSO: ≥20mg/mL | | form | Yellow solid | | pka | 5.80±0.30(Predicted) | | color | yellow |
| Hazard Codes | Xn | | Risk Statements | 22 |
| PD158780 Usage And Synthesis |
| Uses | PD 158780 is a potent tyrosine kinase inhibitor of the epidermal growth factor receptor and has been shown to delay substantial growth of tumors in vivo tumor models. | | General Description | A potent inhibitor of the EGFR tyrosine kinase activity (8 pM). Also inhibits heregulin-stimulated autophosphorylation in SK-BR-3 (IC50 =49 nM) and MDA-MB-453 (IC50 = 52 nM) breast carcinomas. The inhibition is competitive and results from binding of the inhibitor at the ATP site of the enzymes. Inhibits the LPA-stimulated MAP kinase kinase 1/2 (MKK1/2) activation and EGFR tyrosine phosphorylation in HeLa and NIH3T3 cells. | | Biological Activity | Potent inhibitor of ErbB receptor family tyrosine kinases (IC 50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively) that does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G 1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells. | | Biochem/physiol Actions | Cell permeable: yes |
| PD158780 Preparation Products And Raw materials |
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