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| 4-HYDROXYPHENYLRETINAMIDE Basic information |
| Product Name: | 4-HYDROXYPHENYLRETINAMIDE | | Synonyms: | 4-HYDROXYPHENYLRETINAMIDE;4HPR;FENRETINIDE;p-Hydroxyphenylretinamide;4-HPR, Fenretinide, N-(4-Hydroxyphenyl)retinamide;(2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenamide;Fenretinimide;Fenretinide(4-HPR) | | CAS: | 65646-68-6 | | MF: | C26H33NO2 | | MW: | 391.55 | | EINECS: | 200-256-5 | | Product Categories: | Intracellular receptor;Intermediates & Fine Chemicals;Pharmaceuticals;Retinoids;Drug Analogues;Inhibitors | | Mol File: | 65646-68-6.mol |
| 4-HYDROXYPHENYLRETINAMIDE Chemical Properties |
| Melting point | 162-163°C | | Boiling point | 597.6±42.0 °C(Predicted) | | density | 1.081±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Orange solid | | pka | 9.98±0.26(Predicted) | | color | Yellow | | λmax | 362nm(MeOH)(lit.) | | Merck | 14,3998 | | Stability: | Light Sensitive - Protect from Light Exposure | | InChIKey | AKJHMTWEGVYYSE-FXILSDISSA-N | | CAS DataBase Reference | 65646-68-6(CAS DataBase Reference) |
| 4-HYDROXYPHENYLRETINAMIDE Usage And Synthesis |
| Chemical Properties | 4-HYDROXYPHENYLRETINAMIDE is Yellow Powder
| | Uses | 4-HYDROXYPHENYLRETINAMIDE is an effective agent for the chemoprevention and growth modulation of oncogene-induced prostate cancer in the mouse prostate reconstitution model system and may be effective for the chemoprevention of human prostate cancer
| | Uses | A synthetic analog of Vitamin A. | | Uses | Retinoic acid receptor ligand | | Definition | ChEBI: A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in
ivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids. | | General Description | Retinoic acid p-hydroxyanilide is a synthetic analog of retinoid. | | Biological Activity | Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo . Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids. | | Biochem/physiol Actions | Vitamin A acid analogue with antiproliferative activity; induces apoptosis in malignant hemopoietic cell lines. | | references | [1] roberto benelli, stefano monteghirfo, roberta venè, francesca tosettiand nicoletta ferrari.the chemopreventive retinoid 4hpr impairs prostate cancer cell migration and invasion by interfering with fak/akt/gsk3β pathway andβ-catenin stability. molecular cancer.2010, 9:142-154.[2] anita l. sabichi, denver t. hendricks, mary a. bober, michael j. birrer. retinoic acid receptorβexpression and growthinhibition of gynecologic cancer cells by thesynthetic retinoidn-(4-hydroxyphenyl) retinamide. journal of the national cancer institute. 1998, 90(8): 597-605.[3] shi-yong sun, ping yue, and reuben lotan. induction of apoptosis by n-(4-hydroxyphenyl)retinamide andits association with reactive oxygen species, nuclearretinoic acid receptors, and apoptosis-related genes in human prostate carcinoma cells.molecular pharmacology. 1999, 55:403–410. |
| 4-HYDROXYPHENYLRETINAMIDE Preparation Products And Raw materials |
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