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| Sancycline Basic information |
| Product Name: | Sancycline | | Synonyms: | SANCYCLINE;(4S,4aS,5aR,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1-11-dioxo-2-naphthacenecarboxamide;6-Demethyl-6-deoxytetracycline;Bonomycin;GS 2147;Norcycline;Sancycline Hydrochloride;(4S,4aS,5aR,12aS)-4-(Dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-naphthacenecarboxamide | | CAS: | 808-26-4 | | MF: | C21H22N2O7 | | MW: | 414.41 | | EINECS: | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 808-26-4.mol |
| Sancycline Chemical Properties |
| Melting point | 224-2280C (dec) | | Boiling point | 750.9±60.0 °C(Predicted) | | density | 1.61±0.1 g/cm3(Predicted) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | Aqueous Acid (Slightly), Chloroform (Slightly), Methanol (Slightly), Water (Slig | | form | Solid | | pka | 4.50±1.00(Predicted) | | color | Beige to Dark Beige | | Stability: | Hygroscopic | | CAS DataBase Reference | 808-26-4 |
| Sancycline Usage And Synthesis |
| Description | Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 μg/ml, respectively). Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 μg/ml. In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively. | | Chemical Properties | Yellow Solid | | Uses | A semi-synthetic antibiotic related to tetracycline | | Uses | Sancycline is a rare semi-synthetic tetracycline prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of declomycin, first reported in 1962. As the simplest of the early tetracyclines, sancycline was the first to be totally synthesised by Conover and co-workers. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site. | | Uses | Sancycline is a tetracycline bacteriostatic antibiotic which also binds to the Tet repressor protein (TetR). | | Brand name | Bonomycin (Pfizer). |
| Sancycline Preparation Products And Raw materials |
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